InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PFKFB1

Summary

InnateDB Gene

IDBG-71927.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PFKFB1

Gene Name

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

Synonyms

F6PK; HL2K; PFRX

Species

Homo sapiens

Ensembl Gene

ENSG00000158571

Encoded Proteins

IDBP-71929

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

IDBP-71931

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

IDBP-586989

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

IDBP-807965

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:54932961-54998534

Strand

Reverse strand

Band

p11.21

Transcripts

ENST00000375006	ENSP00000364145
ENST00000374992	ENSP00000364131
ENST00000545676	ENSP00000444074
ENST00000614686	ENSP00000480232

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003873	6-phosphofructo-2-kinase activity
GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0019900	kinase binding
GO:0042802	identical protein binding
GO:0070095	fructose-6-phosphate binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006000	fructose metabolic process
GO:0006003	fructose 2,6-bisphosphate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0006112	energy reserve metabolic process
GO:0016311	dephosphorylation
GO:0031100	organ regeneration
GO:0032868	response to insulin
GO:0033133	positive regulation of glucokinase activity
GO:0033762	response to glucagon
GO:0035556	intracellular signal transduction
GO:0042594	response to starvation
GO:0044281	small molecule metabolic process
GO:0046835	carbohydrate phosphorylation
GO:0051384	response to glucocorticoid
GO:0051591	response to cAMP