Homo sapiens Gene: PFKFB1
Summary
InnateDB Gene IDBG-71927.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PFKFB1
Gene Name 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Synonyms F6PK; HL2K; PFRX;
Species Homo sapiens
Ensembl Gene ENSG00000158571
Encoded Proteins
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome X:54932961-54998534
Strand Reverse strand
Band p11.21
Transcripts
ENST00000375006 ENSP00000364145
ENST00000374992 ENSP00000364131
ENST00000545676 ENSP00000444074
ENST00000614686 ENSP00000480232
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003873 6-phosphofructo-2-kinase activity
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0019900 kinase binding
GO:0042802 identical protein binding
GO:0070095 fructose-6-phosphate binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006000 fructose metabolic process
GO:0006003 fructose 2,6-bisphosphate metabolic process
GO:0006006 glucose metabolic process
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0006112 energy reserve metabolic process
GO:0016311 dephosphorylation
GO:0031100 organ regeneration
GO:0032868 response to insulin
GO:0033133 positive regulation of glucokinase activity
GO:0033762 response to glucagon
GO:0035556 intracellular signal transduction
GO:0042594 response to starvation
GO:0044281 small molecule metabolic process
GO:0046835 carbohydrate phosphorylation
GO:0051384 response to glucocorticoid
GO:0051591 response to cAMP
Cellular Component
GO:0005829 cytosol
GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Integration of energy metabolism pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
PKA-mediated phosphorylation of key metabolic factors pathway
Gluconeogenesis pathway
PP2A-mediated dephosphorylation of key metabolic factors pathway
Glycolysis pathway
Metabolism pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
KEGG
Fructose and mannose metabolism pathway
INOH
Fructose Mannose metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.444304
RefSeq NM_001271804 NM_001271805 NM_002625 XM_005262014
HUGO
OMIM
CCDS CCDS14364 CCDS65273
HPRD 02411
IMGT
EMBL
GenPept
RNA Seq Atlas