Version 5.4
Homo sapiens Gene: SPIB
Summary
InnateDB Gene IDBG-64473.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPIB
Gene Name Spi-B transcription factor (Spi-1/PU.1 related), isoform CRA_a; Transcription factor Spi-B; cDNA FLJ57438, highly similar to Transcription factor Spi-B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000142539
Encoded Proteins
IDBP-383801
Spi-B transcription factor (Spi-1/PU.1 related)
IDBP-765386
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:50415799-50428409
Strand Forward strand
Band q13.33
Transcripts
ENST00000439922 ENSP00000391877
ENST00000599632 ENSP00000473233
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003887 DNA-directed DNA polymerase activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006260 DNA replication
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000008193
View Gene Order
ENSBTAG00000043953
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001243998 NM_001243999 NM_001244000 NM_003121
HUGO
OMIM
CCDS CCDS33080 CCDS58674 CCDS59412
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca