Bos taurus Gene: PHF8
Summary
InnateDB Gene IDBG-637450.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHF8
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013289
Encoded Proteins
PHD finger protein 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172943:
The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. Defects in this gene are a cause of mental retardation syndromic X-linked Siderius type (MRXSSD). Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:96802567-96867773
Strand Reverse strand
Band
Transcripts
ENSBTAT00000017673 ENSBTAP00000017673
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005506 iron ion binding
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0032452 histone demethylase activity
GO:0032454 histone demethylase activity (H3-K9 specific)
GO:0035064 methylated histone binding
GO:0035575 histone demethylase activity (H4-K20 specific)
GO:0051864 histone demethylase activity (H3-K36 specific)
GO:0071558 histone demethylase activity (H3-K27 specific)
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0033169 histone H3-K9 demethylation
GO:0035574 histone H4-K20 demethylation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045943 positive regulation of transcription from RNA polymerase I promoter
GO:0061188 negative regulation of chromatin silencing at rDNA
GO:0070544 histone H3-K36 demethylation
GO:0071557 histone H3-K27 demethylation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
HDMs demethylate histones pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
Cell Cycle, Mitotic pathway
Chromatin organization pathway
HDMs demethylate histones pathway
Cell Cycle pathway
M Phase pathway
Condensation of Prophase Chromosomes pathway
Chromatin modifying enzymes pathway
Mitotic Prophase pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.52661
RefSeq XM_002700122 XM_005228232 XM_005228236 XM_005228237 XM_872450
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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