Version 5.4
Mus musculus Gene: Napsa
Summary
InnateDB Gene IDBG-179312.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Napsa
Gene Name napsin A aspartic peptidase
Synonyms KAP; Kdap; NAP1; pronapsin; SNAPA
Species Mus musculus
Ensembl Gene ENSMUSG00000002204
Encoded Proteins
IDBP-179314
napsin A aspartic peptidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131400:
The activation peptides of aspartic proteinases plays role as inhibitors of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:44572432-44586862
Strand Forward strand
Band B3
Transcripts
ENSMUST00000002274 ENSMUSP00000002274
ENSMUST00000153124
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004190 aspartic-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0033619 membrane protein proteolysis
GO:0043129 surfactant homeostasis
Cellular Component
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
GO:0097208 alveolar lamellar body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000131400
View Gene Order
ENSBTAG00000006780
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04142
Lysosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt O09043
TrEMBL Q3U7H1
UniProt Splice Variant
Entrez Gene 16541
UniGene Mm.383181
RefSeq NM_008437
OMIM
CCDS CCDS21212
HPRD
IMGT
MGI ID MGI:109365
MGI Symbol Napsa
EMBL AJ250718 AJ250719 AJ250720 AK152663 BC014813 D88899
GenPept AAH14813 BAA19004 BAE31398 CAB82907
RNA Seq Atlas 16541

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca