Homo sapiens Gene: NAPSA
Summary
InnateDB Gene IDBG-64304.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NAPSA
Gene Name napsin A aspartic peptidase
Synonyms KAP; Kdap; NAP1; NAPA; SNAPA;
Species Homo sapiens
Ensembl Gene ENSG00000131400
Encoded Proteins
napsin A aspartic peptidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The activation peptides of aspartic proteinases plays role as inhibitors of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:50358477-50365830
Strand Reverse strand
Band q13.33
Transcripts
ENST00000253719 ENSP00000253719
ENST00000599181
ENST00000599233 ENSP00000469763
ENST00000598044
ENST00000598915 ENSP00000469061
ENST00000596653
ENST00000597378
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004190 aspartic-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0033619 membrane protein proteolysis
GO:0043129 surfactant homeostasis
Cellular Component
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
GO:0097208 alveolar lamellar body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Lysosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.512843
RefSeq NM_004851
HUGO
OMIM
CCDS CCDS12794
HPRD 07064
IMGT
EMBL
GenPept
RNA Seq Atlas