Version 5.4
Mus musculus Gene: Rapgef4
Summary
InnateDB Gene IDBG-179330.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rapgef4
Gene Name Rap guanine nucleotide exchange factor (GEF) 4
Synonyms 1300003D15Rik; 5730402K07Rik; 6330581N18Rik; EPAC 2; Epac-2; Epac2; mKIAA4040
Species Mus musculus
Ensembl Gene ENSMUSG00000049044
Encoded Proteins
IDBP-179332
Rap guanine nucleotide exchange factor (GEF) 4
IDBP-179334
Rap guanine nucleotide exchange factor (GEF) 4
IDBP-179336
Rap guanine nucleotide exchange factor (GEF) 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000091428:
Gene Information
Type Protein coding
Genomic Location Chromosome 2:71981240-72257474
Strand Forward strand
Band C3
Transcripts
ENSMUST00000090826 ENSMUSP00000088336
ENSMUST00000028525 ENSMUSP00000028525
ENSMUST00000102698 ENSMUSP00000099759
ENSMUST00000149421
ENSMUST00000150234
ENSMUST00000124004
ENSMUST00000122975
ENSMUST00000151236
ENSMUST00000153887
ENSMUST00000156031
ENSMUST00000146970
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0008603 cAMP-dependent protein kinase regulator activity
GO:0017016 Ras GTPase binding
GO:0030552 cAMP binding
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0017156 calcium ion-dependent exocytosis
GO:0017157 regulation of exocytosis
GO:0019933 cAMP-mediated signaling
GO:0030073 insulin secretion
GO:0032318 regulation of Ras GTPase activity
GO:0035556 intracellular signal transduction
GO:0043087 regulation of GTPase activity
GO:0045859 regulation of protein kinase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005952 cAMP-dependent protein kinase complex
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000091428
View Gene Order
ENSBTAG00000020984
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_217323
Integration of energy metabolism pathway
REACT_188937
Metabolism pathway
REACT_230745
Immune System pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_263148
Regulation of insulin secretion pathway
REACT_237855
Rap1 signalling pathway
REACT_229531
Adaptive Immune System pathway
REACT_188257
Signal Transduction pathway
REACT_246176
Integrin alphaIIb beta3 signaling pathway
REACT_249309
Platelet Aggregation (Plug Formation) pathway
REACT_248547
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
KEGG
mmu04670
Leukocyte transendothelial migration pathway
INOH
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_23898
Rap1 signalling pathway
REACT_15523
Integrin alphaIIb beta3 signaling pathway
REACT_278
Platelet Aggregation (Plug Formation) pathway
REACT_18274
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1505
Integration of energy metabolism pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_111217
Metabolism pathway
REACT_604
Hemostasis pathway
KEGG
hsa04670
Leukocyte transendothelial migration pathway
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.196153 Mm.396676
RefSeq NM_001204165 NM_001204166 NM_019688 XM_006499935 XM_006499937
OMIM
CCDS CCDS16120 CCDS57176 CCDS57177
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca