Version 5.4
Homo sapiens Gene: RAPGEF4
Summary
InnateDB Gene IDBG-75192.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAPGEF4
Gene Name Rap guanine nucleotide exchange factor (GEF) 4
Synonyms 2; CAMP-GEFII; CGEF2; EPAC; EPAC 2; EPAC2; Nbla00496
Species Homo sapiens
Ensembl Gene ENSG00000091428
Encoded Proteins
IDBP-236095
Rap guanine nucleotide exchange factor (GEF) 4
IDBP-236097
Rap guanine nucleotide exchange factor (GEF) 4
IDBP-236099
Rap guanine nucleotide exchange factor (GEF) 4
IDBP-293609
Rap guanine nucleotide exchange factor (GEF) 4
IDBP-591200
Rap guanine nucleotide exchange factor (GEF) 4
IDBP-596830
Rap guanine nucleotide exchange factor (GEF) 4
IDBP-587511
Rap guanine nucleotide exchange factor (GEF) 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:172735274-173052893
Strand Forward strand
Band q31.1
Transcripts
ENST00000397087 ENSP00000380276
ENST00000397085 ENSP00000380274
ENST00000397081 ENSP00000380271
ENST00000409036 ENSP00000387104
ENST00000484331
ENST00000464976
ENST00000473003
ENST00000473043
ENST00000466030
ENST00000473182
ENST00000459852
ENST00000484645
ENST00000538974 ENSP00000440135
ENST00000540783 ENSP00000440250
ENST00000535187 ENSP00000438011
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0008603 cAMP-dependent protein kinase regulator activity
GO:0017016 Ras GTPase binding
GO:0030552 cAMP binding
Biological Process
GO:0006112 energy reserve metabolic process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007596 blood coagulation
GO:0017156 calcium ion-dependent exocytosis
GO:0017157 regulation of exocytosis
GO:0019933 cAMP-mediated signaling
GO:0030073 insulin secretion
GO:0030168 platelet activation
GO:0032318 regulation of Ras GTPase activity
GO:0032320 positive regulation of Ras GTPase activity
GO:0035556 intracellular signal transduction
GO:0043087 regulation of GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0044281 small molecule metabolic process
GO:0045859 regulation of protein kinase activity
GO:0050796 regulation of insulin secretion
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005952 cAMP-dependent protein kinase complex
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000049044
View Gene Order
ENSBTAG00000020984
Not yet available
Pathways
NETPATH
REACTOME
REACT_23898
Rap1 signalling pathway
REACT_15523
Integrin alphaIIb beta3 signaling pathway
REACT_278
Platelet Aggregation (Plug Formation) pathway
REACT_18274
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1505
Integration of energy metabolism pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_111217
Metabolism pathway
REACT_604
Hemostasis pathway
KEGG
hsa04670
Leukocyte transendothelial migration pathway
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt Q8WZA2
TrEMBL B7Z278 Q53QY2 Q53TH3 X5D7N4
UniProt Splice Variant
Entrez Gene 11069
UniGene Hs.470646 Hs.604801
RefSeq NM_007023 NM_001100397 NM_001282899 NM_001282900 NM_001282901 XM_005246246 XM_006712205 XM_006712206
HUGO HGNC:16626
OMIM 103950 606058
CCDS CCDS42775 CCDS42776 CCDS63060 CCDS63061 CCDS74604
HPRD 06929
IMGT
EMBL AB027471 AC009484 AC018712 AC019046 AC104086 AK294433 AK294445 AK294914 AK296340 AK304278 AK313084 AK316072 BC024004 BC040183 KJ534925 U78516
GenPept AAD03422 AAH24004 AAH40183 AAY15071 AAY24186 AHW56565 BAB72179 BAG35910 BAH11764 BAH11769 BAH11923 BAH12322 BAH14148 BAH14443
RNA Seq Atlas 11069

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca