Homo sapiens Gene: RAPGEF4
Summary
InnateDB Gene IDBG-75192.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAPGEF4
Gene Name Rap guanine nucleotide exchange factor (GEF) 4
Synonyms 2; CAMP-GEFII; CGEF2; EPAC; EPAC 2; EPAC2; Nbla00496;
Species Homo sapiens
Ensembl Gene ENSG00000091428
Encoded Proteins
Rap guanine nucleotide exchange factor (GEF) 4
Rap guanine nucleotide exchange factor (GEF) 4
Rap guanine nucleotide exchange factor (GEF) 4
Rap guanine nucleotide exchange factor (GEF) 4
Rap guanine nucleotide exchange factor (GEF) 4
Rap guanine nucleotide exchange factor (GEF) 4
Rap guanine nucleotide exchange factor (GEF) 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:172735274-173052893
Strand Forward strand
Band q31.1
Transcripts
ENST00000397087 ENSP00000380276
ENST00000397085 ENSP00000380274
ENST00000397081 ENSP00000380271
ENST00000409036 ENSP00000387104
ENST00000484331
ENST00000464976
ENST00000473003
ENST00000473043
ENST00000466030
ENST00000473182
ENST00000459852
ENST00000484645
ENST00000538974 ENSP00000440135
ENST00000540783 ENSP00000440250
ENST00000535187 ENSP00000438011
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0008603 cAMP-dependent protein kinase regulator activity
GO:0017016 Ras GTPase binding
GO:0030552 cAMP binding
Biological Process
GO:0006112 energy reserve metabolic process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007596 blood coagulation
GO:0017156 calcium ion-dependent exocytosis
GO:0017157 regulation of exocytosis
GO:0019933 cAMP-mediated signaling
GO:0030073 insulin secretion
GO:0030168 platelet activation
GO:0032318 regulation of Ras GTPase activity
GO:0032320 positive regulation of Ras GTPase activity
GO:0035556 intracellular signal transduction
GO:0043087 regulation of GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0044281 small molecule metabolic process
GO:0045859 regulation of protein kinase activity
GO:0050796 regulation of insulin secretion
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005952 cAMP-dependent protein kinase complex
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Integration of energy metabolism pathway
Rap1 signalling pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
Integrin alphaIIb beta3 signaling pathway
Adaptive Immune System pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Immune System pathway
Platelet Aggregation (Plug Formation) pathway
Regulation of insulin secretion pathway
Metabolism pathway
Hemostasis pathway
KEGG
Leukocyte transendothelial migration pathway
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.470646 Hs.604801
RefSeq NM_001100397 NM_001282899 NM_001282900 NM_001282901 NM_007023 XM_005246246 XM_006712205 XM_006712206
HUGO
OMIM
CCDS CCDS42775 CCDS42776 CCDS63060 CCDS63061 CCDS74604
HPRD 06929
IMGT
EMBL
GenPept
RNA Seq Atlas