Mus musculus Gene: Irx3
Summary
InnateDB Gene IDBG-180019.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Irx3
Gene Name Iroquois related homeobox 3 (Drosophila)
Synonyms AI894186
Species Mus musculus
Ensembl Gene ENSMUSG00000031734
Encoded Proteins
Iroquois related homeobox 3 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177508:
IRX3 is a member of the Iroquois homeobox gene family (see IRX1; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998 [PubMed 9427753]). Members of this family appear to play multiple roles during pattern formation of vertebrate embryos (Lewis et al., 1999 [PubMed 10370142]).[supplied by OMIM, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:91798525-91801916
Strand Reverse strand
Band C5
Transcripts
ENSMUST00000093312 ENSMUSP00000091002
ENSMUST00000175795 ENSMUSP00000135488
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001656 metanephros development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007498 mesoderm development
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0072047 proximal/distal pattern formation involved in nephron development
GO:0072086 specification of loop of Henle identity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030424 axon
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.238044
RefSeq NM_001253822 NM_008393
OMIM
CCDS CCDS57630 CCDS57631
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas