Homo sapiens Gene: PIDD
Summary
InnateDB Gene IDBG-18088.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIDD
Gene Name p53-induced death domain protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000177595
Encoded Proteins
p53-induced death domain protein
p53-induced death domain protein
p53-induced death domain protein
p53-induced death domain protein
p53-induced death domain protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:799179-809753
Strand Reverse strand
Band p15.5
Transcripts
ENST00000347755 ENSP00000337797
ENST00000411829 ENSP00000416801
ENST00000525028 ENSP00000436342
ENST00000524486 ENSP00000436146
ENST00000531286 ENSP00000435008
ENST00000527357
ENST00000534525
ENST00000527812
ENST00000528122
ENST00000534649
ENST00000530911
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 38 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005123 death receptor binding
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007165 signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
p53 signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Caspase Cascade in Apoptosis
Direct p53 effectors
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.592290
RefSeq NM_145886 NM_145887
HUGO
OMIM
CCDS CCDS44508 CCDS7716
HPRD 11284
IMGT
EMBL
GenPept
RNA Seq Atlas