InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PIDD

Summary

InnateDB Gene

IDBG-18088.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIDD

Gene Name

p53-induced death domain protein

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000177595

Encoded Proteins

IDBP-18092

p53-induced death domain protein

IDBP-360836

p53-induced death domain protein

IDBP-602317

p53-induced death domain protein

IDBP-587243

p53-induced death domain protein

IDBP-588111

p53-induced death domain protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:799179-809753

Strand

Reverse strand

Band

p15.5

Transcripts

ENST00000347755	ENSP00000337797
ENST00000411829	ENSP00000416801
ENST00000525028	ENSP00000436342
ENST00000524486	ENSP00000436146
ENST00000531286	ENSP00000435008
ENST00000527357
ENST00000534525
ENST00000527812
ENST00000528122
ENST00000534649
ENST00000530911

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005123	death receptor binding
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007165	signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001235	positive regulation of apoptotic signaling pathway
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000025507

View Gene Order

ENSBTAG00000019634

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04115

p53 signaling pathway pathway

INOH

PID NCI

caspase_pathway

Caspase Cascade in Apoptosis

p53downstreampathway

Direct p53 effectors

Cross-References

SwissProt

Q9HB75

TrEMBL

UniProt Splice Variant

Entrez Gene

55367

UniGene

Hs.592290

RefSeq

NM_145887 NM_145886

HUGO

HGNC:16491

OMIM

605247

CCDS

CCDS44508 CCDS7716

HPRD

11284

IMGT

EMBL

AB208832 AB208949 AB209529 AF229178 AF274972 AF465246 AK074893 AL833849 BC014904

GenPept

AAF69491 AAG13461 AAH14904 AAP97716 BAC11272 BAD92069 BAD92186 BAD92766 CAD38708

RNA Seq Atlas

102725026 55367