Mus musculus Gene: Prmt1
Summary
InnateDB Gene IDBG-180907.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prmt1
Gene Name protein arginine N-methyltransferase 1
Synonyms 6720434D09Rik; AW214366; Hrmt1l2; Mrmt1;
Species Mus musculus
Ensembl Gene ENSMUSG00000052429
Encoded Proteins
protein arginine N-methyltransferase 1
protein arginine N-methyltransferase 1
protein arginine N-methyltransferase 1
protein arginine N-methyltransferase 1
protein arginine N-methyltransferase 1
protein arginine N-methyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] PRMT1 is a protein arginine methyltransferase and a novel and crucial negative regulator of STAT1 activation that controls PIAS1-mediated repression by arginine methylation.
[Homo sapiens] Reversible arginine methylation of TRAF6 is regulated by PRMT1 and JMJD6 and this in turn regulates TRAF6-dependent TLR signalling.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126457:
This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:44975989-44986492
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000085387 ENSMUSP00000082505
ENSMUST00000045325 ENSMUSP00000045365
ENSMUST00000107843 ENSMUSP00000103474
ENSMUST00000107842 ENSMUSP00000103473
ENSMUST00000107840 ENSMUSP00000103471
ENSMUST00000153576 ENSMUSP00000117536
ENSMUST00000125886
ENSMUST00000127531
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 93 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 93 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008170 N-methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0008469 histone-arginine N-methyltransferase activity
GO:0016274 protein-arginine N-methyltransferase activity
GO:0016275 [cytochrome c]-arginine N-methyltransferase activity
GO:0016740 transferase activity
GO:0030519 snoRNP binding
GO:0035241 protein-arginine omega-N monomethyltransferase activity
GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity
GO:0042054 histone methyltransferase activity
GO:0042802 identical protein binding
GO:0044020 histone methyltransferase activity (H4-R3 specific)
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006355 regulation of transcription, DNA-templated
GO:0006479 protein methylation
GO:0008152 metabolic process
GO:0016571 histone methylation
GO:0018216 peptidyl-arginine methylation
GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0031175 neuron projection development
GO:0035247 peptidyl-arginine omega-N-methylation
GO:0043985 histone H4-R3 methylation
GO:0045653 negative regulation of megakaryocyte differentiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Chromatin organization pathway
Chromatin modifying enzymes pathway
RMTs methylate histone arginines pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
AndrogenReceptor pathway
REACTOME
Chromatin organization pathway
RMTs methylate histone arginines pathway
Chromatin modifying enzymes pathway
KEGG
INOH
PID BIOCARTA
Control of gene expression by vitamin d receptor [Biocarta view]
Btg family proteins and cell cycle regulation [Biocarta view]
PID NCI
Direct p53 effectors
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.27545
RefSeq NM_001252476 NM_001252477 NM_019830 XM_006540640
OMIM
CCDS CCDS21222 CCDS57547
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas