InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Prmt1

Summary

InnateDB Gene

IDBG-180907.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prmt1

Gene Name

protein arginine N-methyltransferase 1

Synonyms

6720434D09Rik; AW214366; Hrmt1l2; Mrmt1;

Species

Mus musculus

Ensembl Gene

ENSMUSG00000052429

Encoded Proteins

IDBP-180909

protein arginine N-methyltransferase 1

IDBP-180911

protein arginine N-methyltransferase 1

IDBP-265808

protein arginine N-methyltransferase 1

IDBP-265810

protein arginine N-methyltransferase 1

IDBP-265814

protein arginine N-methyltransferase 1

IDBP-536596

protein arginine N-methyltransferase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 19136629

[Homo sapiens] PRMT1 is a protein arginine methyltransferase and a novel and crucial negative regulator of STAT1 activation that controls PIAS1-mediated repression by arginine methylation.

PMID 26221041

[Homo sapiens] Reversible arginine methylation of TRAF6 is regulated by PRMT1 and JMJD6 and this in turn regulates TRAF6-dependent TLR signalling.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126457:
This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:44975989-44986492

Strand

Reverse strand

Band

Transcripts

ENSMUST00000085387	ENSMUSP00000082505
ENSMUST00000045325	ENSMUSP00000045365
ENSMUST00000107843	ENSMUSP00000103474
ENSMUST00000107842	ENSMUSP00000103473
ENSMUST00000107840	ENSMUSP00000103471
ENSMUST00000153576	ENSMUSP00000117536
ENSMUST00000125886
ENSMUST00000127531

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 93 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	93 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008170	N-methyltransferase activity
GO:0008276	protein methyltransferase activity
GO:0008469	histone-arginine N-methyltransferase activity
GO:0016274	protein-arginine N-methyltransferase activity
GO:0016275	[cytochrome c]-arginine N-methyltransferase activity
GO:0016740	transferase activity
GO:0030519	snoRNP binding
GO:0035241	protein-arginine omega-N monomethyltransferase activity
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity
GO:0042054	histone methyltransferase activity
GO:0042802	identical protein binding
GO:0044020	histone methyltransferase activity (H4-R3 specific)
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006355	regulation of transcription, DNA-templated
GO:0006479	protein methylation
GO:0008152	metabolic process
GO:0016571	histone methylation
GO:0018216	peptidyl-arginine methylation
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0031175	neuron projection development
GO:0035247	peptidyl-arginine omega-N-methylation
GO:0043985	histone H4-R3 methylation
GO:0045653	negative regulation of megakaryocyte differentiation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0043234	protein complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

Method

Confidence

Comments

ENSG00000126457

View Gene Order

Ortholuge

SSD Ortholog

Ortholog supports species divergence

ENSBTAG00000006646

Not yet available

Ortholuge

SSD Ortholog

Ortholog supports species divergence

Pathways

NETPATH

REACTOME

REACT_218274

Chromatin organization pathway

REACT_202766

Chromatin modifying enzymes pathway

REACT_244207

RMTs methylate histone arginines pathway

KEGG

INOH

PID BIOCARTA

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_2

AndrogenReceptor pathway

REACTOME

REACT_172623

Chromatin organization pathway

REACT_228108

RMTs methylate histone arginines pathway

REACT_172633

Chromatin modifying enzymes pathway

KEGG

INOH

PID BIOCARTA

100007

Control of gene expression by vitamin d receptor [Biocarta view]

100224

Btg family proteins and cell cycle regulation [Biocarta view]

PID NCI

p53downstreampathway

Direct p53 effectors

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.27545

RefSeq

NM_001252476 NM_001252477 NM_019830 XM_006540640

OMIM

CCDS

CCDS21222 CCDS57547

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas