Homo sapiens Gene: PRMT1
Summary
InnateDB Gene IDBG-63299.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRMT1
Gene Name protein arginine methyltransferase 1
Synonyms ANM1; HCP1; HRMT1L2; IR1B4;
Species Homo sapiens
Ensembl Gene ENSG00000126457
Encoded Proteins
protein arginine methyltransferase 1
protein arginine methyltransferase 1
protein arginine methyltransferase 1
protein arginine methyltransferase 1
protein arginine methyltransferase 1
protein arginine methyltransferase 1
protein arginine methyltransferase 1
protein arginine methyltransferase 1
protein arginine methyltransferase 1
protein arginine methyltransferase 1
protein arginine methyltransferase 1
protein arginine methyltransferase 1
protein arginine methyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PRMT1 is a protein arginine methyltransferase and a novel and crucial negative regulator of STAT1 activation that controls PIAS1-mediated repression by arginine methylation.
Reversible arginine methylation of TRAF6 is regulated by PRMT1 and JMJD6 and this in turn regulates TRAF6-dependent TLR signalling.
Entrez Gene
Summary This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:49675786-49689029
Strand Forward strand
Band q13.33
Transcripts
ENST00000391851 ENSP00000375724
ENST00000454376 ENSP00000406162
ENST00000529284 ENSP00000432349
ENST00000532489 ENSP00000433556
ENST00000527382 ENSP00000432538
ENST00000528623 ENSP00000434911
ENST00000534465 ENSP00000431957
ENST00000534280 ENSP00000432050
ENST00000534676
ENST00000525915
ENST00000525616
ENST00000524771 ENSP00000433480
ENST00000529836 ENSP00000437273
ENST00000526224 ENSP00000432788
ENST00000527412 ENSP00000436732
ENST00000529650
ENST00000530070
ENST00000530361
ENST00000528126
ENST00000527866
ENST00000610806 ENSP00000484505
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 206 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 206 [view]
Protein-Protein 201 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008170 N-methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0008469 histone-arginine N-methyltransferase activity
GO:0016274 protein-arginine N-methyltransferase activity
GO:0016275 [cytochrome c]-arginine N-methyltransferase activity
GO:0016740 transferase activity
GO:0030519 snoRNP binding
GO:0035241 protein-arginine omega-N monomethyltransferase activity
GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity
GO:0042054 histone methyltransferase activity
GO:0042802 identical protein binding
GO:0044020 histone methyltransferase activity (H4-R3 specific)
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006355 regulation of transcription, DNA-templated
GO:0006479 protein methylation
GO:0007166 cell surface receptor signaling pathway
GO:0008152 metabolic process
GO:0016571 histone methylation
GO:0018216 peptidyl-arginine methylation
GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0031175 neuron projection development
GO:0035247 peptidyl-arginine omega-N-methylation
GO:0043985 histone H4-R3 methylation
GO:0045087 innate immune response (InnateDB)
GO:0045653 negative regulation of megakaryocyte differentiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
REACTOME
Chromatin organization pathway
RMTs methylate histone arginines pathway
Chromatin modifying enzymes pathway
KEGG
INOH
PID BIOCARTA
Control of gene expression by vitamin d receptor [Biocarta view]
Btg family proteins and cell cycle regulation [Biocarta view]
PID NCI
Direct p53 effectors
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.20521
RefSeq NM_001207042 NM_001536 NM_198318
HUGO
OMIM
CCDS CCDS42592 CCDS46145 CCDS74425
HPRD 04257
IMGT
EMBL
GenPept
RNA Seq Atlas