InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PRMT1

Summary

InnateDB Gene

IDBG-63299.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRMT1

Gene Name

protein arginine methyltransferase 1

Synonyms

ANM1; HCP1; HRMT1L2; IR1B4

Species

Homo sapiens

Ensembl Gene

ENSG00000126457

Encoded Proteins

IDBP-246857

protein arginine methyltransferase 1

IDBP-383387

protein arginine methyltransferase 1

IDBP-586613

protein arginine methyltransferase 1

IDBP-594305

protein arginine methyltransferase 1

IDBP-593671

protein arginine methyltransferase 1

IDBP-599679

protein arginine methyltransferase 1

IDBP-587398

protein arginine methyltransferase 1

IDBP-601674

protein arginine methyltransferase 1

IDBP-600857

protein arginine methyltransferase 1

IDBP-587909

protein arginine methyltransferase 1

IDBP-585358

protein arginine methyltransferase 1

IDBP-589577

protein arginine methyltransferase 1

IDBP-812813

protein arginine methyltransferase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 19136629

PRMT1 is a protein arginine methyltransferase and a novel and crucial negative regulator of STAT1 activation that controls PIAS1-mediated repression by arginine methylation.

PMID 26221041

Reversible arginine methylation of TRAF6 is regulated by PRMT1 and JMJD6 and this in turn regulates TRAF6-dependent TLR signalling.

Entrez Gene

Summary

This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:49675786-49689029

Strand

Forward strand

Band

q13.33

Transcripts

ENST00000391851	ENSP00000375724
ENST00000454376	ENSP00000406162
ENST00000529284	ENSP00000432349
ENST00000532489	ENSP00000433556
ENST00000527382	ENSP00000432538
ENST00000528623	ENSP00000434911
ENST00000534465	ENSP00000431957
ENST00000534280	ENSP00000432050
ENST00000534676
ENST00000525915
ENST00000525616
ENST00000524771	ENSP00000433480
ENST00000529836	ENSP00000437273
ENST00000526224	ENSP00000432788
ENST00000527412	ENSP00000436732
ENST00000529650
ENST00000530070
ENST00000530361
ENST00000528126
ENST00000527866
ENST00000610806	ENSP00000484505

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 206 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	206 [view]
Protein-Protein	201 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008170	N-methyltransferase activity
GO:0008276	protein methyltransferase activity
GO:0008469	histone-arginine N-methyltransferase activity
GO:0016274	protein-arginine N-methyltransferase activity
GO:0016275	[cytochrome c]-arginine N-methyltransferase activity
GO:0016740	transferase activity
GO:0030519	snoRNP binding
GO:0035241	protein-arginine omega-N monomethyltransferase activity
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity
GO:0042054	histone methyltransferase activity
GO:0042802	identical protein binding
GO:0044020	histone methyltransferase activity (H4-R3 specific)
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006355	regulation of transcription, DNA-templated
GO:0006479	protein methylation
GO:0007166	cell surface receptor signaling pathway
GO:0008152	metabolic process
GO:0016571	histone methylation
GO:0018216	peptidyl-arginine methylation
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0031175	neuron projection development
GO:0035247	peptidyl-arginine omega-N-methylation
GO:0043985	histone H4-R3 methylation
GO:0045087	innate immune response (InnateDB)
GO:0045653	negative regulation of megakaryocyte differentiation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0043234	protein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000052429

View Gene Order

ENSBTAG00000006646

Not yet available

Pathways

NETPATH

NetPath_2

AndrogenReceptor pathway

REACTOME

REACT_172623

Chromatin organization pathway

REACT_228108

RMTs methylate histone arginines pathway

REACT_172633

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

p53downstreampathway

Direct p53 effectors

Cross-References

SwissProt

TrEMBL

E9PI83

UniProt Splice Variant

Entrez Gene

3276

UniGene

Hs.20521

RefSeq

NM_001207042 NM_001536 NM_198318

HUGO

HGNC:5187

OMIM

602950

CCDS

CCDS42592 CCDS46145 CCDS74425

HPRD

04257

IMGT

EMBL

AC011495

GenPept

RNA Seq Atlas

102724071 3276