Bos taurus Gene: HRMT1L2
Summary
InnateDB Gene IDBG-640647.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HRMT1L2
Gene Name protein arginine N-methyltransferase 1
Synonyms HRMT1L2;
Species Bos taurus
Ensembl Gene ENSBTAG00000006646
Encoded Proteins
protein arginine N-methyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] PRMT1 is a protein arginine methyltransferase and a novel and crucial negative regulator of STAT1 activation that controls PIAS1-mediated repression by arginine methylation.
[Homo sapiens] Reversible arginine methylation of TRAF6 is regulated by PRMT1 and JMJD6 and this in turn regulates TRAF6-dependent TLR signalling.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126457:
This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:56534833-56545053
Strand Forward strand
Band
Transcripts
ENSBTAT00000008734 ENSBTAP00000008734
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 97 interaction(s) predicted by orthology.
Predicted by orthology
Total 97 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008168 methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0008469 histone-arginine N-methyltransferase activity
GO:0016740 transferase activity
GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity
GO:0044020 histone methyltransferase activity (H4-R3 specific)
Biological Process
GO:0001701 in utero embryonic development
GO:0006355 regulation of transcription, DNA-templated
GO:0006479 protein methylation
GO:0008152 metabolic process
GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0032259 methylation
GO:0043985 histone H4-R3 methylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
AndrogenReceptor pathway
REACTOME
Chromatin organization pathway
RMTs methylate histone arginines pathway
Chromatin modifying enzymes pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
RMTs methylate histone arginines pathway
KEGG
INOH
PID BIOCARTA
Control of gene expression by vitamin d receptor [Biocarta view]
Btg family proteins and cell cycle regulation [Biocarta view]
PID NCI
Direct p53 effectors
Cross-References
SwissProt
TrEMBL Q5E949
UniProt Splice Variant
Entrez Gene 520388
UniGene Bt.52357
RefSeq NM_001015624 XM_005219283 XM_005219284
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC109796 BT021071 DAAA02047482 DAAA02047483
GenPept AAI09797 AAX09088
RNA Seq Atlas 520388
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

(Move your mouse over the image to view a more detailed version)