InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HRMT1L2

Summary

InnateDB Gene

IDBG-640647.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HRMT1L2

Gene Name

protein arginine N-methyltransferase 1

Synonyms

HRMT1L2

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006646

Encoded Proteins

IDBP-692931

protein arginine N-methyltransferase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 19136629

[Homo sapiens] PRMT1 is a protein arginine methyltransferase and a novel and crucial negative regulator of STAT1 activation that controls PIAS1-mediated repression by arginine methylation.

PMID 26221041

[Homo sapiens] Reversible arginine methylation of TRAF6 is regulated by PRMT1 and JMJD6 and this in turn regulates TRAF6-dependent TLR signalling.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126457:
This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:56534833-56545053

Strand

Forward strand

Band

Transcripts

ENSBTAT00000008734

ENSBTAP00000008734

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 97 interaction(s) predicted by orthology.

Predicted by orthology
Total	97 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008168	methyltransferase activity
GO:0008276	protein methyltransferase activity
GO:0008469	histone-arginine N-methyltransferase activity
GO:0016740	transferase activity
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity
GO:0044020	histone methyltransferase activity (H4-R3 specific)

Biological Process

GO:0001701	in utero embryonic development
GO:0006355	regulation of transcription, DNA-templated
GO:0006479	protein methylation
GO:0008152	metabolic process
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0032259	methylation
GO:0043985	histone H4-R3 methylation