Homo sapiens Gene: SERPINA10
Summary
InnateDB Gene IDBG-18111.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINA10
Gene Name serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000140093
Encoded Proteins
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:94280455-94293271
Strand Reverse strand
Band q32.13
Transcripts
ENST00000261994 ENSP00000261994
ENST00000393096 ENSP00000376809
ENST00000554723 ENSP00000450896
ENST00000554173 ENSP00000450971
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0008201 heparin binding
Biological Process
GO:0007596 blood coagulation
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q9UK55
TrEMBL A0A024R6I6
UniProt Splice Variant
Entrez Gene 51156
UniGene Hs.118620
RefSeq NM_001100607 NM_016186 XM_005267733 XM_006720159 XM_006725163 XM_006725164
HUGO HGNC:15996
OMIM 605271
CCDS CCDS9923
HPRD 09245
IMGT
EMBL AF181467 AY358597 BC022261 BX248011 CH471061 EF621762
GenPept AAD53962 AAH22261 AAQ88960 ABR09269 CAD62339 EAW81565 EAW81566
RNA Seq Atlas 51156