Version 5.4
Mus musculus Gene: Cry1
Summary
InnateDB Gene IDBG-181230.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cry1
Gene Name cryptochrome 1 (photolyase-like)
Synonyms AU020726; AU021000; Phll1
Species Mus musculus
Ensembl Gene ENSMUSG00000020038
Encoded Proteins
IDBP-181232
cryptochrome 1 (photolyase-like)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of this gene results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:85131702-85185054
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000020227 ENSMUSP00000020227
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 57 [view]
Protein-Protein 57 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000989 transcription factor binding transcription factor activity
GO:0001047 core promoter binding
GO:0003690 double-stranded DNA binding
GO:0003913 DNA photolyase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0009881 photoreceptor activity
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0035257 nuclear hormone receptor binding
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006094 gluconeogenesis
GO:0006281 DNA repair
GO:0006351 transcription, DNA-templated
GO:0006975 DNA damage induced protein phosphorylation
GO:0007165 signal transduction
GO:0007623 circadian rhythm
GO:0018298 protein-chromophore linkage
GO:0019915 lipid storage
GO:0031397 negative regulation of protein ubiquitination
GO:0032868 response to insulin
GO:0032922 circadian regulation of gene expression
GO:0033762 response to glucagon
GO:0042593 glucose homeostasis
GO:0042752 regulation of circadian rhythm
GO:0042754 negative regulation of circadian rhythm
GO:0043153 entrainment of circadian clock by photoperiod
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:2000001 regulation of DNA damage checkpoint
GO:2000323 negative regulation of glucocorticoid receptor signaling pathway
GO:2000850 negative regulation of glucocorticoid secretion
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000008405
View Gene Order
ENSBTAG00000010149
Not yet available
Pathways
NETPATH
REACTOME
REACT_24972
Circadian Clock pathway
REACT_200794
Mus musculus biological processes pathway
REACT_241925
Circadian Clock pathway
REACT_198620
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
KEGG
mmu04710
Circadian rhythm pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_111118
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_24941
Circadian Clock pathway
KEGG
hsa04710
Circadian rhythm pathway
INOH
PID NCI
Cross-References
SwissProt P97784
TrEMBL
UniProt Splice Variant
Entrez Gene 12952
UniGene Mm.26237
RefSeq NM_007771 XM_006513186
OMIM
CCDS CCDS24089
HPRD
IMGT
MGI ID MGI:1270841
MGI Symbol Cry1
EMBL AB000777 AF156986 AK162460 BC022174 BC085499
GenPept AAD39548 AAH22174 AAH85499 BAA19175 BAE36931
RNA Seq Atlas 12952

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca