Version 5.4
Homo sapiens Gene: CRY1
Summary
InnateDB Gene IDBG-55047.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRY1
Gene Name cryptochrome 1 (photolyase-like)
Synonyms PHLL1
Species Homo sapiens
Ensembl Gene ENSG00000008405
Encoded Proteins
IDBP-55049
cryptochrome 1 (photolyase-like)
IDBP-590011
cryptochrome 1 (photolyase-like)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Aug 2012]
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:106991364-107093829
Strand Reverse strand
Band q23.3
Transcripts
ENST00000008527 ENSP00000008527
ENST00000552790
ENST00000549356 ENSP00000447738
ENST00000546722
ENST00000550633
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 27 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000989 transcription factor binding transcription factor activity
GO:0001047 core promoter binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003913 DNA photolyase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0009882 blue light photoreceptor activity
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0035257 nuclear hormone receptor binding
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006094 gluconeogenesis
GO:0006281 DNA repair
GO:0006351 transcription, DNA-templated
GO:0006975 DNA damage induced protein phosphorylation
GO:0007623 circadian rhythm
GO:0009785 blue light signaling pathway
GO:0018298 protein-chromophore linkage
GO:0019915 lipid storage
GO:0031397 negative regulation of protein ubiquitination
GO:0032868 response to insulin
GO:0032922 circadian regulation of gene expression
GO:0033762 response to glucagon
GO:0042593 glucose homeostasis
GO:0042752 regulation of circadian rhythm
GO:0042754 negative regulation of circadian rhythm
GO:0043153 entrainment of circadian clock by photoperiod
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:2000001 regulation of DNA damage checkpoint
GO:2000323 negative regulation of glucocorticoid receptor signaling pathway
GO:2000850 negative regulation of glucocorticoid secretion
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020038
View Gene Order
ENSBTAG00000010149
Not yet available
Pathways
NETPATH
REACTOME
REACT_111118
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_24941
Circadian Clock pathway
KEGG
hsa04710
Circadian rhythm pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H0YHT0
UniProt Splice Variant
Entrez Gene 1407
UniGene Hs.151573 Hs.739819
RefSeq NM_004075
HUGO HGNC:2384
OMIM 601933
CCDS CCDS9112
HPRD 09050
IMGT
EMBL AC007541 AC078929
GenPept
RNA Seq Atlas 1407

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca