InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CRY1

Summary

InnateDB Gene

IDBG-637730.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRY1

Gene Name

cryptochrome-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010149

Encoded Proteins

IDBP-689765

cryptochrome-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:70606115-70701030

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000057061

ENSBTAP00000051134

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000989	transcription factor binding transcription factor activity
GO:0001047	core promoter binding
GO:0003690	double-stranded DNA binding
GO:0003913	DNA photolyase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019900	kinase binding
GO:0019901	protein kinase binding
GO:0019902	phosphatase binding
GO:0035257	nuclear hormone receptor binding
GO:0042826	histone deacetylase binding
GO:0043130	ubiquitin binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006094	gluconeogenesis
GO:0006281	DNA repair
GO:0006975	DNA damage induced protein phosphorylation
GO:0007623	circadian rhythm
GO:0019915	lipid storage
GO:0031397	negative regulation of protein ubiquitination
GO:0032868	response to insulin
GO:0032922	circadian regulation of gene expression
GO:0033762	response to glucagon
GO:0042593	glucose homeostasis
GO:0042752	regulation of circadian rhythm
GO:0042754	negative regulation of circadian rhythm
GO:0043153	entrainment of circadian clock by photoperiod
GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:2000001	regulation of DNA damage checkpoint
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway
GO:2000850	negative regulation of glucocorticoid secretion