Version 5.4
Mus musculus Gene: Agps
Summary
InnateDB Gene IDBG-181523.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Agps
Gene Name alkylglycerone phosphate synthase
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000042410
Encoded Proteins
IDBP-181525
alkylglycerone phosphate synthase
IDBP-257027
alkylglycerone phosphate synthase
IDBP-719580
IDBP-719594
IDBP-718669
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000018510:
This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:75832177-75931350
Strand Forward strand
Band C3
Transcripts
ENSMUST00000047232 ENSMUSP00000041967
ENSMUST00000111952 ENSMUSP00000107583
ENSMUST00000176056 ENSMUSP00000134773
ENSMUST00000176973 ENSMUSP00000134806
ENSMUST00000177204
ENSMUST00000175646 ENSMUSP00000135457
ENSMUST00000176626
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008609 alkylglycerone-phosphate synthase activity
GO:0008762 UDP-N-acetylmuramate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0050660 flavin adenine dinucleotide binding
GO:0071949 FAD binding
Biological Process
GO:0008610 lipid biosynthetic process
GO:0008611 ether lipid biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000018510
View Gene Order
ENSBTAG00000009897
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_258151
Plasmalogen biosynthesis pathway
REACT_246750
Peroxisomal lipid metabolism pathway
KEGG
mmu00565
Ether lipid metabolism pathway
mmu04146
Peroxisome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1407
Plasmalogen biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_16957
Peroxisomal lipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00565
Ether lipid metabolism pathway
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A2AL49 Q8BKC4
UniProt Splice Variant
Entrez Gene 228061
UniGene Mm.31227 Mm.448862
RefSeq NM_172666
OMIM
CCDS CCDS16151
HPRD
IMGT
MGI ID MGI:2443065
MGI Symbol Agps
EMBL AK053686 AL773533
GenPept BAC35474
RNA Seq Atlas 228061

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca