Version 5.4
Mus musculus Gene: Aldh3a1
Summary
InnateDB Gene IDBG-182377.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aldh3a1
Gene Name aldehyde dehydrogenase family 3, subfamily A1
Synonyms Ahd-4; Ahd4; Aldh; Aldh3
Species Mus musculus
Ensembl Gene ENSMUSG00000019102
Encoded Proteins
IDBP-182379
aldehyde dehydrogenase family 3, subfamily A1
IDBP-263947
aldehyde dehydrogenase family 3, subfamily A1
IDBP-536133
aldehyde dehydrogenase family 3, subfamily A1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108602:
Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:61207537-61218421
Strand Forward strand
Band B2
Transcripts
ENSMUST00000019246 ENSMUSP00000019246
ENSMUST00000108716 ENSMUSP00000104356
ENSMUST00000147792 ENSMUSP00000118613
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003995 acyl-CoA dehydrogenase activity
GO:0004028 3-chloroallyl aldehyde dehydrogenase activity
GO:0004029 aldehyde dehydrogenase (NAD) activity
GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity
GO:0008106 alcohol dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Biological Process
GO:0001666 response to hypoxia
GO:0006081 cellular aldehyde metabolic process
GO:0007568 aging
GO:0007584 response to nutrient
GO:0008152 metabolic process
GO:0008218 bioluminescence
GO:0008284 positive regulation of cell proliferation
GO:0014070 response to organic cyclic compound
GO:0042493 response to drug
GO:0051384 response to glucocorticoid
GO:0051591 response to cAMP
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000108602
View Gene Order
ENSBTAG00000021113
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00410
beta-Alanine metabolism pathway
mmu00350
Tyrosine metabolism pathway
mmu00340
Histidine metabolism pathway
mmu00010
Glycolysis / Gluconeogenesis pathway
mmu00360
Phenylalanine metabolism pathway
mmu00980
Metabolism of xenobiotics by cytochrome P450 pathway
mmu00982
Drug metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00340
Histidine metabolism pathway
hsa00360
Phenylalanine metabolism pathway
hsa00350
Tyrosine metabolism pathway
hsa00410
beta-Alanine metabolism pathway
hsa00980
Metabolism of xenobiotics by cytochrome P450 pathway
hsa00982
Drug metabolism pathway
INOH
INOH website
Phenylalanine degradation pathway
INOH website
Tyrosine metabolism pathway
INOH website
Histidine degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.4257
RefSeq NM_001112725 NM_007436 XM_006532023 XM_006532024 XM_006532025 XM_006532026 XM_006532027
OMIM
CCDS CCDS24808
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca