Homo sapiens Gene: DDX4 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-21276.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | DDX4 | ||||||||||||||||||||||
Gene Name | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000152670 | ||||||||||||||||||||||
Encoded Proteins |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a homolog of VASA proteins in Drosophila and several other species. The gene is specifically expressed in the germ cell lineage in both sexes and functions in germ cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 5:55738017-55817157 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | q11.2 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | D6RIB2 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 54514 | ||||||||||||||||||||||
UniGene | Hs.223581 | ||||||||||||||||||||||
RefSeq | NM_001142549 NM_001166533 NM_001166534 NM_024415 XM_005248545 | ||||||||||||||||||||||
HUGO | HGNC:18700 | ||||||||||||||||||||||
OMIM | 605281 | ||||||||||||||||||||||
CCDS | CCDS3969 CCDS47208 CCDS54854 CCDS54855 | ||||||||||||||||||||||
HPRD | 05593 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC016632 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 54514 | ||||||||||||||||||||||