Homo sapiens Gene: DDX4
Summary
InnateDB Gene IDBG-21276.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDX4
Gene Name DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000152670
Encoded Proteins
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a homolog of VASA proteins in Drosophila and several other species. The gene is specifically expressed in the germ cell lineage in both sexes and functions in germ cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:55738017-55817157
Strand Forward strand
Band q11.2
Transcripts
ENST00000354991 ENSP00000347087
ENST00000353507 ENSP00000334167
ENST00000505374 ENSP00000424838
ENST00000506511 ENSP00000427167
ENST00000508580
ENST00000515709 ENSP00000424779
ENST00000506848 ENSP00000421960
ENST00000514679 ENSP00000424112
ENST00000511491 ENSP00000427522
ENST00000503129 ENSP00000423102
ENST00000514278 ENSP00000425359
ENST00000511853 ENSP00000423123
ENST00000507645 ENSP00000430431
ENST00000509312
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
Biological Process
GO:0006200 ATP catabolic process
GO:0007141 male meiosis I
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0030317 sperm motility
GO:0032880 regulation of protein localization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030529 ribonucleoprotein complex
GO:0033391 chromatoid body
GO:0048471 perinuclear region of cytoplasm
GO:0071546 pi-body
GO:0071547 piP-body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q9NQI0
TrEMBL D6RAF5 D6RCM4
UniProt Splice Variant
Entrez Gene 54514
UniGene Hs.223581
RefSeq NM_001166533 NM_024415 NM_001166534 NM_001142549 XM_005248545
HUGO HGNC:18700
OMIM 605281
CCDS CCDS54854 CCDS47208 CCDS3969 CCDS54855
HPRD 05593
IMGT
EMBL AC016632 AF262962 AK093439 AK292417 AL137462 AY004154 BC047455 BC088362 CH471123
GenPept AAF72705 AAF86585 AAH47455 AAH88362 BAF85106 BAG52716 CAB70750 EAW54929
RNA Seq Atlas 54514