InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fst

Summary

InnateDB Gene

IDBG-183755.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fst

Gene Name

follistatin

Synonyms

AL033346; FS

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021765

Encoded Proteins

IDBP-183757

follistatin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene binds to and negatively regulates activin, as well as other members of the transforming growth factor beta family, and acts to prevent uncontrolled cellular proliferation. This protein also contains a heparin-binding sequence. It is expressed in many of the tissues in which activin is synthesized and is thought to clear activin from the circulation by attachment to the cell surface. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms, including FST315 and FST288, that differ at their C-terminus. Another isoform, FST303 is thought to be produced by proteolytic cleavage of FST315. These isoforms differ in their localization and in their ability to bind heparin. While FST315 is a circulating protein, FST288 is tissue-bound, and FST303 is gonad-specific. While deletion of all isoforms results in embryonic lethality, expression of just FST288 is sufficient for embryonic development, but the resultant mice have fertility defects. [provided by RefSeq, Aug 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:114452262-114458730

Strand

Reverse strand

Band

D2.2

Transcripts

ENSMUST00000022287

ENSMUSP00000022287

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043395	heparan sulfate proteoglycan binding
GO:0048185	activin binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0002244	hematopoietic progenitor cell differentiation
GO:0007276	gamete generation
GO:0007389	pattern specification process
GO:0008585	female gonad development
GO:0030509	BMP signaling pathway
GO:0031069	hair follicle morphogenesis
GO:0032926	negative regulation of activin receptor signaling pathway
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043616	keratinocyte proliferation
GO:0045596	negative regulation of cell differentiation
GO:0051798	positive regulation of hair follicle development