Version 5.4
Homo sapiens Gene: CLEC9A
Summary
InnateDB Gene IDBG-18377.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLEC9A
Gene Name C-type lectin domain family 9, member A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000197992
Encoded Proteins
IDBP-18379
C-type lectin domain family 9, member A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22483800
CLEC9A is restricted to dendritic cells, and specifically recognizes filamentous actin from necrotic cells. CLEC9A ligand engagement is necessary for the priming of cytotoxic T cells against necrotic cell antigens.
InnateDB Annotation from Orthologs
Summary
PMID 22483800
[Mus musculus] Clec9a is restricted to dendritic cells, and specifically recognizes filamentous actin from necrotic cells. Clec9a ligand engagement is necessary for the priming of cytotoxic T cells against necrotic cell antigens. (Demonstrated in human)
Entrez Gene
Summary CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).[supplied by OMIM, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:10030677-10066027
Strand Forward strand
Band p13.2
Transcripts
ENST00000355819 ENSP00000348074
ENST00000544751
ENST00000538482
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0030246 carbohydrate binding
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0045087 innate immune response (InnateDB)
GO:0050715 positive regulation of cytokine secretion
Cellular Component
GO:0009986 cell surface
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000046080
View Gene Order
ENSBTAG00000009537
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.531189 Hs.606503
RefSeq NM_207345
HUGO
OMIM
CCDS CCDS8611
HPRD 16723
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca