|Homo sapiens Gene: CLEC9A|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||C-type lectin domain family 9, member A|
C-type lectin domain family 9, member A
|Useful resources||Stemformatics EHFPI ImmGen|
CLEC9A is restricted to dendritic cells, and specifically recognizes filamentous actin from necrotic cells. CLEC9A ligand engagement is necessary for the priming of cytotoxic T cells against necrotic cell antigens.
|InnateDB Annotation from Orthologs|
[Mus musculus] Clec9a is restricted to dendritic cells, and specifically recognizes filamentous actin from necrotic cells. Clec9a ligand engagement is necessary for the priming of cytotoxic T cells against necrotic cell antigens. (Demonstrated in human)
CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).[supplied by OMIM, Aug 2008]
|Genomic Location||Chromosome 12:10030677-10066027|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
|UniProt Splice Variant|
|RNA Seq Atlas|