InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tnfrsf21

Summary

InnateDB Gene

IDBG-184035.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfrsf21

Gene Name

tumor necrosis factor receptor superfamily, member 21

Synonyms

AA959878; DR6; R74815; TR7

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023915

Encoded Proteins

IDBP-184037

tumor necrosis factor receptor superfamily, member 21

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146072:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. Knockout studies in mice suggested that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:43016555-43089188

Strand

Forward strand

Band

Transcripts

ENSMUST00000024708

ENSMUSP00000024708

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001783	B cell apoptotic process
GO:0002250	adaptive immune response
GO:0006915	apoptotic process
GO:0006959	humoral immune response
GO:0007165	signal transduction
GO:0030889	negative regulation of B cell proliferation
GO:0031642	negative regulation of myelination
GO:0042130	negative regulation of T cell proliferation
GO:0042552	myelination
GO:0048713	regulation of oligodendrocyte differentiation
GO:0050852	T cell receptor signaling pathway
GO:0051402	neuron apoptotic process
GO:0071356	cellular response to tumor necrosis factor
GO:0097252	oligodendrocyte apoptotic process
GO:2000663	negative regulation of interleukin-5 secretion
GO:2000666	negative regulation of interleukin-13 secretion
GO:2001180	negative regulation of interleukin-10 secretion

Cellular Component

GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0031226	intrinsic component of plasma membrane