Version 5.4
Homo sapiens Gene: TNFRSF21
Summary
InnateDB Gene IDBG-90063.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFRSF21
Gene Name tumor necrosis factor receptor superfamily, member 21
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000146072
Encoded Proteins
IDBP-90065
tumor necrosis factor receptor superfamily, member 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. Knockout studies in mice suggested that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:47231532-47309905
Strand Reverse strand
Band p12.3
Transcripts
ENST00000296861 ENSP00000296861
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 9 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001783 B cell apoptotic process
GO:0002250 adaptive immune response
GO:0006915 apoptotic process
GO:0006959 humoral immune response
GO:0007165 signal transduction
GO:0030889 negative regulation of B cell proliferation
GO:0031642 negative regulation of myelination
GO:0042130 negative regulation of T cell proliferation
GO:0042552 myelination
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0048713 regulation of oligodendrocyte differentiation
GO:0050852 T cell receptor signaling pathway
GO:0051402 neuron apoptotic process
GO:0071356 cellular response to tumor necrosis factor
GO:0097252 oligodendrocyte apoptotic process
GO:2000663 negative regulation of interleukin-5 secretion
GO:2000666 negative regulation of interleukin-13 secretion
GO:2001180 negative regulation of interleukin-10 secretion
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0030424 axon
GO:0031226 intrinsic component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023915
View Gene Order
ENSBTAG00000020054
Not yet available
Pathways
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt O75509
TrEMBL A0A024RD71
UniProt Splice Variant
Entrez Gene 27242
UniGene
RefSeq NM_014452
HUGO HGNC:13469
OMIM 605732
CCDS CCDS4921
HPRD 05759
IMGT
EMBL AF068868 AK315560 AL096801 AY358304 BC010241 BC017730 BC021572 BT007420 CH471081
GenPept AAC34583 AAH10241 AAH17730 AAH21572 AAP36088 AAQ88671 BAG37936 CAB75692 EAX04315 EAX04316 EAX04318
RNA Seq Atlas 27242

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca