InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TNFRSF21

Summary

InnateDB Gene

IDBG-632394.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFRSF21

Gene Name

tumor necrosis factor receptor superfamily member 21

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020054

Encoded Proteins

IDBP-683998

tumor necrosis factor receptor superfamily member 21

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146072:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. Knockout studies in mice suggested that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:20410839-20474989

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000026719

ENSBTAP00000026719

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001783	B cell apoptotic process
GO:0002250	adaptive immune response
GO:0006915	apoptotic process
GO:0006959	humoral immune response
GO:0007165	signal transduction
GO:0030889	negative regulation of B cell proliferation
GO:0031642	negative regulation of myelination
GO:0042130	negative regulation of T cell proliferation
GO:0042552	myelination
GO:0048713	regulation of oligodendrocyte differentiation
GO:0050852	T cell receptor signaling pathway
GO:0051402	neuron apoptotic process
GO:0071356	cellular response to tumor necrosis factor
GO:0097252	oligodendrocyte apoptotic process
GO:2000663	negative regulation of interleukin-5 secretion
GO:2000666	negative regulation of interleukin-13 secretion
GO:2001180	negative regulation of interleukin-10 secretion