Version 5.4
Mus musculus Gene: Pam
Summary
InnateDB Gene IDBG-184778.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pam
Gene Name peptidylglycine alpha-amidating monooxygenase
Synonyms PHM
Species Mus musculus
Ensembl Gene ENSMUSG00000026335
Encoded Proteins
IDBP-184780
peptidylglycine alpha-amidating monooxygenase
IDBP-184782
peptidylglycine alpha-amidating monooxygenase
IDBP-532424
peptidylglycine alpha-amidating monooxygenase
IDBP-536130
peptidylglycine alpha-amidating monooxygenase
IDBP-538311
peptidylglycine alpha-amidating monooxygenase
IDBP-540286
peptidylglycine alpha-amidating monooxygenase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145730:
This gene encodes a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL). These catalytic domains work sequentially to catalyze neuroendocrine peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene but some of their full length sequences are not yet known. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:97795114-98095646
Strand Reverse strand
Band D
Transcripts
ENSMUST00000058762 ENSMUSP00000057112
ENSMUST00000097625 ENSMUSP00000095228
ENSMUST00000159041 ENSMUSP00000124284
ENSMUST00000161567 ENSMUSP00000125418
ENSMUST00000162681 ENSMUSP00000125133
ENSMUST00000159585
ENSMUST00000160210
ENSMUST00000162803
ENSMUST00000159131
ENSMUST00000161071
ENSMUST00000159841 ENSMUSP00000124479
ENSMUST00000159428
ENSMUST00000162426
ENSMUST00000163007
ENSMUST00000186731
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004497 monooxygenase activity
GO:0004504 peptidylglycine monooxygenase activity
GO:0004598 peptidylamidoglycolate lyase activity
GO:0005507 copper ion binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
GO:0019901 protein kinase binding
GO:0031418 L-ascorbic acid binding
Biological Process
GO:0001519 peptide amidation
GO:0001666 response to hypoxia
GO:0001676 long-chain fatty acid metabolic process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006518 peptide metabolic process
GO:0007417 central nervous system development
GO:0007507 heart development
GO:0007595 lactation
GO:0009268 response to pH
GO:0009404 toxin metabolic process
GO:0018032 protein amidation
GO:0022602 ovulation cycle process
GO:0032355 response to estradiol
GO:0032956 regulation of actin cytoskeleton organization
GO:0042476 odontogenesis
GO:0042493 response to drug
GO:0046688 response to copper ion
GO:0050708 regulation of protein secretion
GO:0051260 protein homooligomerization
GO:0051384 response to glucocorticoid
GO:0055114 oxidation-reduction process
GO:0060135 maternal process involved in female pregnancy
GO:0060173 limb development
Cellular Component
GO:0005615 extracellular space
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0030658 transport vesicle membrane
GO:0030667 secretory granule membrane
GO:0043005 neuron projection
GO:0043204 perikaryon
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000145730
View Gene Order
ENSBTAG00000012387
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.5121
RefSeq NM_013626 XM_006529243 XM_006529244 XM_006529248
OMIM
CCDS CCDS48331
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca