InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PAM

Summary

InnateDB Gene

IDBG-35530.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PAM

Gene Name

peptidylglycine alpha-amidating monooxygenase

Synonyms

PAL; PHM;

Species

Homo sapiens

Ensembl Gene

ENSG00000145730

Encoded Proteins

IDBP-35532

peptidylglycine alpha-amidating monooxygenase

IDBP-35536

peptidylglycine alpha-amidating monooxygenase

IDBP-35538

peptidylglycine alpha-amidating monooxygenase

IDBP-35540

peptidylglycine alpha-amidating monooxygenase

IDBP-35544

peptidylglycine alpha-amidating monooxygenase

IDBP-374352

peptidylglycine alpha-amidating monooxygenase

IDBP-374389

peptidylglycine alpha-amidating monooxygenase

IDBP-481628

peptidylglycine alpha-amidating monooxygenase

IDBP-482640

peptidylglycine alpha-amidating monooxygenase

IDBP-484014

peptidylglycine alpha-amidating monooxygenase

IDBP-479855

peptidylglycine alpha-amidating monooxygenase

IDBP-476367

peptidylglycine alpha-amidating monooxygenase

IDBP-481399

peptidylglycine alpha-amidating monooxygenase

IDBP-482178

peptidylglycine alpha-amidating monooxygenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL). These catalytic domains work sequentially to catalyze neuroendocrine peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene but some of their full length sequences are not yet known. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:102753981-103031105

Strand

Forward strand

Band

q21.1

Transcripts

ENST00000379799	ENSP00000369125
ENST00000304400	ENSP00000306100
ENST00000345721	ENSP00000302544
ENST00000346918	ENSP00000282992
ENST00000348126	ENSP00000314638
ENST00000438793	ENSP00000396493
ENST00000455264	ENSP00000403461
ENST00000505654	ENSP00000421569
ENST00000508060
ENST00000510208
ENST00000506127
ENST00000512073	ENSP00000420851
ENST00000502472
ENST00000509523
ENST00000511839	ENSP00000426448
ENST00000511477	ENSP00000421823
ENST00000506006	ENSP00000423611
ENST00000509832	ENSP00000423763
ENST00000513648
ENST00000509636
ENST00000506260
ENST00000505372
ENST00000511429
ENST00000510006
ENST00000515456
ENST00000504691	ENSP00000424203
ENST00000504456

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004497	monooxygenase activity
GO:0004504	peptidylglycine monooxygenase activity
GO:0004598	peptidylamidoglycolate lyase activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
GO:0031418	L-ascorbic acid binding

Biological Process

GO:0001519	peptide amidation
GO:0006518	peptide metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

Method

Confidence

Comments

ENSMUSG00000026335

View Gene Order

Ortholuge

SSD Ortholog

Ortholog supports species divergence

ENSBTAG00000012387

Not yet available

Ortholuge

SSD Ortholog

Ortholog supports species divergence

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.369430 Hs.738567

RefSeq

NM_000919 NM_001177306 NM_138766 NM_138821 NM_138822 XM_006714632 XM_006714633 XM_006714634 XM_006714635 XM_006714636 XM_006714637 XM_006714638 XM_006714639 XM_006714640

HUGO

OMIM

CCDS

CCDS4092 CCDS4093 CCDS4094 CCDS43348 CCDS54885

HPRD

01361

IMGT

EMBL

GenPept

RNA Seq Atlas