Homo sapiens Gene: PAM | |||||||||||||||||||||
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Summary | |||||||||||||||||||||
InnateDB Gene | IDBG-35530.6 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | PAM | ||||||||||||||||||||
Gene Name | peptidylglycine alpha-amidating monooxygenase | ||||||||||||||||||||
Synonyms | PAL; PHM | ||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||
Ensembl Gene | ENSG00000145730 | ||||||||||||||||||||
Encoded Proteins |
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
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Protein Structure | |||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||
Summary |
This gene encodes a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL). These catalytic domains work sequentially to catalyze neuroendocrine peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene but some of their full length sequences are not yet known. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||
Genomic Location | Chromosome 5:102753981-103031105 | ||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||
Band | q21.1 | ||||||||||||||||||||
Transcripts | |||||||||||||||||||||
Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Cross-References | |||||||||||||||||||||
SwissProt | |||||||||||||||||||||
TrEMBL | |||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||
UniGene | Hs.369430 Hs.738567 | ||||||||||||||||||||
RefSeq | NM_000919 NM_001177306 NM_138766 NM_138821 NM_138822 XM_006714632 XM_006714633 XM_006714634 XM_006714635 XM_006714636 XM_006714637 XM_006714638 XM_006714639 XM_006714640 | ||||||||||||||||||||
HUGO | |||||||||||||||||||||
OMIM | |||||||||||||||||||||
CCDS | CCDS4092 CCDS4093 CCDS4094 CCDS43348 CCDS54885 | ||||||||||||||||||||
HPRD | 01361 | ||||||||||||||||||||
IMGT | |||||||||||||||||||||
EMBL | |||||||||||||||||||||
GenPept | |||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||