Homo sapiens Gene: PAM
Summary
InnateDB Gene IDBG-35530.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAM
Gene Name peptidylglycine alpha-amidating monooxygenase
Synonyms PAL; PHM;
Species Homo sapiens
Ensembl Gene ENSG00000145730
Encoded Proteins
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
peptidylglycine alpha-amidating monooxygenase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL). These catalytic domains work sequentially to catalyze neuroendocrine peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene but some of their full length sequences are not yet known. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:102753981-103031105
Strand Forward strand
Band q21.1
Transcripts
ENST00000379799 ENSP00000369125
ENST00000304400 ENSP00000306100
ENST00000345721 ENSP00000302544
ENST00000346918 ENSP00000282992
ENST00000348126 ENSP00000314638
ENST00000438793 ENSP00000396493
ENST00000455264 ENSP00000403461
ENST00000505654 ENSP00000421569
ENST00000508060
ENST00000510208
ENST00000506127
ENST00000512073 ENSP00000420851
ENST00000502472
ENST00000509523
ENST00000511839 ENSP00000426448
ENST00000511477 ENSP00000421823
ENST00000506006 ENSP00000423611
ENST00000509832 ENSP00000423763
ENST00000513648
ENST00000509636
ENST00000506260
ENST00000505372
ENST00000511429
ENST00000510006
ENST00000515456
ENST00000504691 ENSP00000424203
ENST00000504456
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004497 monooxygenase activity
GO:0004504 peptidylglycine monooxygenase activity
GO:0004598 peptidylamidoglycolate lyase activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
GO:0031418 L-ascorbic acid binding
Biological Process
GO:0001519 peptide amidation
GO:0006518 peptide metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.369430 Hs.738567
RefSeq NM_000919 NM_001177306 NM_138766 NM_138821 NM_138822 XM_006714632 XM_006714633 XM_006714634 XM_006714635 XM_006714636 XM_006714637 XM_006714638 XM_006714639 XM_006714640
HUGO
OMIM
CCDS CCDS4092 CCDS4093 CCDS4094 CCDS43348 CCDS54885
HPRD 01361
IMGT
EMBL
GenPept
RNA Seq Atlas