Bos taurus Gene: PAM
Summary
InnateDB Gene IDBG-646608.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAM
Gene Name peptidyl-glycine alpha-amidating monooxygenase precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012387
Encoded Proteins
peptidyl-glycine alpha-amidating monooxygenase
peptidyl-glycine alpha-amidating monooxygenase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145730:
This gene encodes a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL). These catalytic domains work sequentially to catalyze neuroendocrine peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene but some of their full length sequences are not yet known. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:104321898-104501791
Strand Forward strand
Band
Transcripts
ENSBTAT00000016445 ENSBTAP00000016445
ENSBTAT00000016466 ENSBTAP00000016466
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004497 monooxygenase activity
GO:0004504 peptidylglycine monooxygenase activity
GO:0004598 peptidylamidoglycolate lyase activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
Biological Process
GO:0001519 peptide amidation
GO:0006518 peptide metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL F1MZB4 F1MZN4
UniProt Splice Variant
Entrez Gene 280890
UniGene Bt.12303
RefSeq NM_173948 XM_005209762 XM_005209763 XM_005209764
HUGO HGNC:8596
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02021477 DAAA02021478 DAAA02021479 DAAA02021480 DAAA02021481 DAAA02021482
GenPept
RNA Seq Atlas 280890
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

(Move your mouse over the image to view a more detailed version)