Homo sapiens Gene: SLC6A1
Summary
InnateDB Gene IDBG-18538.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC6A1
Gene Name solute carrier family 6 (neurotransmitter transporter, GABA), member 1
Synonyms GABATHG; GABATR; GAT1;
Species Homo sapiens
Ensembl Gene ENSG00000157103
Encoded Proteins
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:10992724-11039247
Strand Forward strand
Band p25.3
Transcripts
ENST00000287766 ENSP00000287766
ENST00000425938 ENSP00000411689
ENST00000462473
ENST00000460480
ENST00000495636
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005328 neurotransmitter:sodium symporter activity
GO:0005332 gamma-aminobutyric acid:sodium symporter activity
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006836 neurotransmitter transport
GO:0007268 synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0007612 learning
GO:0009636 response to toxic substance
GO:0009744 response to sucrose stimulus
GO:0010033 response to organic substance
GO:0010243 response to organonitrogen compound
GO:0010288 response to lead ion
GO:0014054 positive regulation of gamma-aminobutyric acid secretion
GO:0014070 response to organic cyclic compound
GO:0014074 response to purine-containing compound
GO:0032229 negative regulation of synaptic transmission, GABAergic
GO:0032355 response to estradiol
GO:0042220 response to cocaine
GO:0051260 protein homooligomerization
GO:0051592 response to calcium ion
GO:0051939 gamma-aminobutyric acid import
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0043005 neuron projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Neuronal System pathway
Reuptake of GABA pathway
GABA synthesis, release, reuptake and degradation pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Release Cycle pathway
Na+/Cl- dependent neurotransmitter transporters pathway
SLC-mediated transmembrane transport pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.443874
RefSeq NM_003042 XM_005265410 XM_005265411 XM_006713306
HUGO
OMIM
CCDS CCDS2603
HPRD 00664
IMGT
EMBL
GenPept
RNA Seq Atlas