InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC6A1

Summary

InnateDB Gene

IDBG-18538.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC6A1

Gene Name

solute carrier family 6 (neurotransmitter transporter, GABA), member 1

Synonyms

GABATHG; GABATR; GAT1

Species

Homo sapiens

Ensembl Gene

ENSG00000157103

Encoded Proteins

IDBP-18540

solute carrier family 6 (neurotransmitter transporter, GABA), member 1

IDBP-363245

solute carrier family 6 (neurotransmitter transporter, GABA), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:10992724-11039247

Strand

Forward strand

Band

p25.3

Transcripts

ENST00000287766	ENSP00000287766
ENST00000425938	ENSP00000411689
ENST00000462473
ENST00000460480
ENST00000495636

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005328	neurotransmitter:sodium symporter activity
GO:0005332	gamma-aminobutyric acid:sodium symporter activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0006836	neurotransmitter transport
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0007612	learning
GO:0009636	response to toxic substance
GO:0009744	response to sucrose stimulus
GO:0010033	response to organic substance
GO:0010243	response to organonitrogen compound
GO:0010288	response to lead ion
GO:0014054	positive regulation of gamma-aminobutyric acid secretion
GO:0014070	response to organic cyclic compound
GO:0014074	response to purine-containing compound
GO:0032229	negative regulation of synaptic transmission, GABAergic
GO:0032355	response to estradiol
GO:0042220	response to cocaine
GO:0051260	protein homooligomerization
GO:0051592	response to calcium ion
GO:0051939	gamma-aminobutyric acid import
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0043005	neuron projection