Mus musculus Gene: Cox10 | |||||||||||||||||||||
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Summary | |||||||||||||||||||||
InnateDB Gene | IDBG-185691.6 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | Cox10 | ||||||||||||||||||||
Gene Name | COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) | ||||||||||||||||||||
Synonyms | 2410004F01Rik; AU042636 | ||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||
Ensembl Gene | ENSMUSG00000042148 | ||||||||||||||||||||
Encoded Proteins |
COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)
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Protein Structure |
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Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000006695:
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||
Genomic Location | Chromosome 11:63962627-64079468 | ||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||
Band | B3 | ||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||
NETPATH | |||||||||||||||||||||
REACTOME |
Metabolism pathway
Heme biosynthesis pathway
Metabolism of porphyrins pathway
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KEGG |
Oxidative phosphorylation pathway
Porphyrin and chlorophyll metabolism pathway
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INOH | |||||||||||||||||||||
PID NCI | |||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||
NETPATH | |||||||||||||||||||||
REACTOME |
Heme biosynthesis pathway
Metabolism of porphyrins pathway
Metabolism pathway
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KEGG |
Oxidative phosphorylation pathway
Porphyrin and chlorophyll metabolism pathway
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INOH | |||||||||||||||||||||
PID NCI | |||||||||||||||||||||
Cross-References | |||||||||||||||||||||
SwissProt | Q8CFY5 | ||||||||||||||||||||
TrEMBL | Q3U3N1 Q3UDN4 | ||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | 70383 | ||||||||||||||||||||
UniGene | Mm.340211 | ||||||||||||||||||||
RefSeq | NM_178379 XM_006534168 | ||||||||||||||||||||
OMIM | |||||||||||||||||||||
CCDS | CCDS24839 | ||||||||||||||||||||
HPRD | |||||||||||||||||||||
IMGT | |||||||||||||||||||||
MGI ID | MGI:1917633 | ||||||||||||||||||||
MGI Symbol | Cox10 | ||||||||||||||||||||
EMBL | AK149999 AK154668 AL603889 AL663033 BC038046 CH466601 | ||||||||||||||||||||
GenPept | AAH38046 BAE29227 BAE32754 CAI25610 CAI26029 EDL10389 | ||||||||||||||||||||
RNA Seq Atlas | 70383 | ||||||||||||||||||||