InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cox10

Summary

InnateDB Gene

IDBG-185691.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cox10

Gene Name

COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)

Synonyms

2410004F01Rik; AU042636

Species

Mus musculus

Ensembl Gene

ENSMUSG00000042148

Encoded Proteins

IDBP-185693

COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000006695:
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:63962627-64079468

Strand

Reverse strand

Band

Transcripts

ENSMUST00000049091	ENSMUSP00000040138
ENSMUST00000125702

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004129	cytochrome-c oxidase activity
GO:0004659	prenyltransferase activity
GO:0008495	protoheme IX farnesyltransferase activity

Biological Process

GO:0000266	mitochondrial fission
GO:0006783	heme biosynthetic process
GO:0006784	heme a biosynthetic process
GO:0007005	mitochondrion organization
GO:0008535	respiratory chain complex IV assembly
GO:0009060	aerobic respiration
GO:0017004	cytochrome complex assembly
GO:0045333	cellular respiration
GO:0048034	heme O biosynthetic process
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000006695

View Gene Order

ENSBTAG00000015294

Not yet available

Pathways

NETPATH

REACTOME

REACT_188937

Metabolism pathway

REACT_203298

Heme biosynthesis pathway

REACT_233360

Metabolism of porphyrins pathway

KEGG

mmu00190

Oxidative phosphorylation pathway

mmu00860

Porphyrin and chlorophyll metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_9465

Heme biosynthesis pathway

REACT_9431

Metabolism of porphyrins pathway

REACT_111217

Metabolism pathway

KEGG

hsa00190

Oxidative phosphorylation pathway

hsa00860

Porphyrin and chlorophyll metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

Q8CFY5

TrEMBL

Q3U3N1 Q3UDN4

UniProt Splice Variant

Entrez Gene

70383

UniGene

Mm.340211

RefSeq

NM_178379 XM_006534168

OMIM

CCDS

CCDS24839

HPRD

IMGT

MGI ID

MGI:1917633

MGI Symbol

Cox10

EMBL

AK149999 AK154668 AL603889 AL663033 BC038046 CH466601

GenPept

AAH38046 BAE29227 BAE32754 CAI25610 CAI26029 EDL10389

RNA Seq Atlas

70383