InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: COX10

Summary

InnateDB Gene

IDBG-637337.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COX10

Gene Name

protoheme IX farnesyltransferase, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015294

Encoded Proteins

IDBP-689336

protoheme IX farnesyltransferase, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000006695:
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:32696437-32804796

Strand

Forward strand

Band

Transcripts

ENSBTAT00000020336

ENSBTAP00000020336

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004129	cytochrome-c oxidase activity
GO:0004659	prenyltransferase activity
GO:0008495	protoheme IX farnesyltransferase activity
GO:0016740	transferase activity

Biological Process

GO:0000266	mitochondrial fission
GO:0006783	heme biosynthetic process
GO:0006784	heme a biosynthetic process
GO:0007005	mitochondrion organization
GO:0008535	respiratory chain complex IV assembly
GO:0009060	aerobic respiration
GO:0017004	cytochrome complex assembly
GO:0045333	cellular respiration
GO:0048034	heme O biosynthetic process
GO:1902600	hydrogen ion transmembrane transport