Homo sapiens Gene: C6
Summary
InnateDB Gene IDBG-18604.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C6
Gene Name complement component 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000039537
Encoded Proteins
complement component 6
complement component 6
complement component 6
complement component 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Complement component six is one of five components that interact to form the cytolytic membrane attack complex (MAC)
Entrez Gene
Summary This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:41142234-41261438
Strand Reverse strand
Band p13.1
Transcripts
ENST00000337836 ENSP00000338861
ENST00000263413 ENSP00000263413
ENST00000417809 ENSP00000396565
ENST00000433294 ENSP00000401578
ENST00000461473
ENST00000511470
ENST00000475349
ENST00000473450
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006956 complement activation
GO:0006958 complement activation, classical pathway
GO:0019835 cytolysis
GO:0030449 regulation of complement activation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005579 membrane attack complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Immune System pathway
Regulation of Complement cascade pathway
Complement cascade pathway
Terminal pathway of complement pathway
KEGG
Complement and coagulation cascades pathway
Prion diseases pathway
Systemic lupus erythematosus pathway
INOH
PID BIOCARTA
Alternative complement pathway [Biocarta view]
Classical complement pathway [Biocarta view]
Lectin induced complement pathway [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.481992
RefSeq NM_000065 NM_001115131 XM_005248357
HUGO
OMIM
CCDS CCDS3936
HPRD 01956
IMGT
EMBL
GenPept
RNA Seq Atlas