Homo sapiens Gene: OLR1
Summary
InnateDB Gene IDBG-18612.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OLR1
Gene Name oxidized low density lipoprotein (lectin-like) receptor 1
Synonyms CLEC8A; LOX1; LOXIN; SCARE1; SLOX1;
Species Homo sapiens
Ensembl Gene ENSG00000173391
Encoded Proteins
oxidized low density lipoprotein (lectin-like) receptor 1
oxidized low density lipoprotein (lectin-like) receptor 1
oxidized low density lipoprotein (lectin-like) receptor 1
oxidized low density lipoprotein (lectin-like) receptor 1
oxidized low density lipoprotein (lectin-like) receptor 1
oxidized low density lipoprotein (lectin-like) receptor 1
oxidized low density lipoprotein (lectin-like) receptor 1
oxidized low density lipoprotein (lectin-like) receptor 1
oxidized low density lipoprotein (lectin-like) receptor 1
oxidized low density lipoprotein (lectin-like) receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer\'s disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:10158301-10172138
Strand Reverse strand
Band p13.2
Transcripts
ENST00000309539 ENSP00000309124
ENST00000339968 ENSP00000340572
ENST00000432556 ENSP00000405116
ENST00000544577 ENSP00000444457
ENST00000543993 ENSP00000445085
ENST00000545927 ENSP00000439251
ENST00000536989
ENST00000539518 ENSP00000442389
ENST00000538745 ENSP00000438925
ENST00000538873 ENSP00000438744
ENST00000543414 ENSP00000444068
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005041 low-density lipoprotein receptor activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0006508 proteolysis
GO:0006898 receptor-mediated endocytosis
GO:0006954 inflammatory response
GO:0007159 leukocyte cell-cell adhesion
GO:0007596 blood coagulation
GO:0008015 blood circulation
GO:0008219 cell death
GO:0042157 lipoprotein metabolic process
GO:0042542 response to hydrogen peroxide
GO:0050900 leukocyte migration
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0043235 receptor complex
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cell surface interactions at the vascular wall pathway
Hemostasis pathway
KEGG
PPAR signaling pathway pathway
Phagosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.412484
RefSeq NM_001172632 NM_001172633 NM_002543
HUGO
OMIM
CCDS CCDS53745 CCDS53746 CCDS8618
HPRD 04003
IMGT
EMBL
GenPept
RNA Seq Atlas