Mus musculus Gene: Dnajc3
Summary
InnateDB Gene IDBG-186994.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dnajc3
Gene Name DnaJ (Hsp40) homolog, subfamily C, member 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000022136
Encoded Proteins
DnaJ (Hsp40) homolog, subfamily C, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102580:
This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:118937932-118981702
Strand Forward strand
Band E4
Transcripts
ENSMUST00000022734 ENSMUSP00000022734
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004860 protein kinase inhibitor activity
GO:0005515 protein binding
GO:0051087 chaperone binding
GO:0051787 misfolded protein binding
Biological Process
GO:0006469 negative regulation of protein kinase activity
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0051603 proteolysis involved in cellular protein catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0005790 smooth endoplasmic reticulum
GO:0005829 cytosol
GO:0016020 membrane
GO:0031205 endoplasmic reticulum Sec complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Unfolded Protein Response (UPR) pathway
Metabolism of proteins pathway
IRE1alpha activates chaperones pathway
XBP1(S) activates chaperone genes pathway
KEGG
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
IRE1alpha activates chaperones pathway
Unfolded Protein Response (UPR) pathway
Influenza Infection pathway
XBP1(S) activates chaperone genes pathway
Influenza Viral RNA Transcription and Replication pathway
Metabolism of proteins pathway
Influenza Life Cycle pathway
Viral mRNA Translation pathway
Disease pathway
KEGG
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
Double stranded rna induced gene expression [Biocarta view]
PID NCI
Cross-References
SwissProt Q91YW3
TrEMBL Q3UFV9
UniProt Splice Variant
Entrez Gene 100037258
UniGene Mm.12616 Mm.420881 Mm.472181
RefSeq NM_008929
OMIM
CCDS CCDS37012
HPRD
IMGT
MGI ID MGI:107373
MGI Symbol Dnajc3
EMBL AK148270 BC013766 CH466544 U28423
GenPept AAC52592 AAH13766 BAE28450 EDL00581
RNA Seq Atlas 100037258