Version 5.4
| Homo sapiens Gene: KLRD1 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-18739.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | KLRD1 | ||||||||||||||||||
| Gene Name | killer cell lectin-like receptor subfamily D, member 1 | ||||||||||||||||||
| Synonyms | CD94 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000134539 | ||||||||||||||||||
| Encoded Proteins |
killer cell lectin-like receptor subfamily D, member 1
killer cell lectin-like receptor subfamily D, member 1
killer cell lectin-like receptor subfamily D, member 1
killer cell lectin-like receptor subfamily D, member 1
killer cell lectin-like receptor subfamily D, member 1
killer cell lectin-like receptor subfamily D, member 1
killer cell lectin-like receptor subfamily D, member 1
killer cell lectin-like receptor subfamily D, member 1
killer cell lectin-like receptor subfamily D, member 1
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 12:10226058-10329600 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | p13.2 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
DAP12 signaling pathway
DAP12 interactions pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Innate Immune System pathway
Adaptive Immune System pathway
Immune System pathway
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| KEGG |
Antigen processing and presentation pathway
Natural killer cell mediated cytotoxicity pathway
Graft-versus-host disease pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.562457 Hs.668357 | ||||||||||||||||||
| RefSeq | NM_001114396 NM_002262 NM_007334 XM_005253363 XM_006719068 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS8621 CCDS8622 | ||||||||||||||||||
| HPRD | 04204 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||