Homo sapiens Gene: KLRD1
Summary
InnateDB Gene IDBG-18739.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLRD1
Gene Name killer cell lectin-like receptor subfamily D, member 1
Synonyms CD94;
Species Homo sapiens
Ensembl Gene ENSG00000134539
Encoded Proteins
killer cell lectin-like receptor subfamily D, member 1
killer cell lectin-like receptor subfamily D, member 1
killer cell lectin-like receptor subfamily D, member 1
killer cell lectin-like receptor subfamily D, member 1
killer cell lectin-like receptor subfamily D, member 1
killer cell lectin-like receptor subfamily D, member 1
killer cell lectin-like receptor subfamily D, member 1
killer cell lectin-like receptor subfamily D, member 1
killer cell lectin-like receptor subfamily D, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:10226058-10329600
Strand Forward strand
Band p13.2
Transcripts
ENST00000344825 ENSP00000344858
ENST00000336164 ENSP00000338130
ENST00000350274 ENSP00000310929
ENST00000381908 ENSP00000371333
ENST00000544747 ENSP00000438669
ENST00000540271
ENST00000538997
ENST00000543420 ENSP00000441074
ENST00000543777 ENSP00000443584
ENST00000539374 ENSP00000438514
ENST00000539792 ENSP00000437880
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0045087 innate immune response
GO:0050776 regulation of immune response
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
DAP12 signaling pathway
Innate Immune System pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Adaptive Immune System pathway
Immune System pathway
DAP12 interactions pathway
KEGG
Antigen processing and presentation pathway
Natural killer cell mediated cytotoxicity pathway
Graft-versus-host disease pathway
INOH
PID BIOCARTA
Ras-independent pathway in nk cell-mediated cytotoxicity [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL F5GX94
UniProt Splice Variant
Entrez Gene 3824
UniGene Hs.562457 Hs.668357
RefSeq NM_001114396 NM_002262 NM_007334 XM_005253363 XM_006719068
HUGO HGNC:6378
OMIM 602894
CCDS CCDS8621 CCDS8622
HPRD 04204
IMGT
EMBL AC022075 AC115676
GenPept
RNA Seq Atlas 3824