Homo sapiens Gene: FBXO4
Summary
InnateDB Gene IDBG-18832.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO4
Gene Name F-box protein 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000151876
Encoded Proteins
F-box protein 4
F-box protein 4
F-box protein 4
F-box protein 4
F-box protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:41925254-41941743
Strand Forward strand
Band p13.1
Transcripts
ENST00000281623 ENSP00000281623
ENST00000296812 ENSP00000296812
ENST00000513496 ENSP00000424750
ENST00000504463 ENSP00000424991
ENST00000509134 ENSP00000421749
ENST00000506496
ENST00000505566
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 21 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0000723 telomere maintenance
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031398 positive regulation of protein ubiquitination
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005737 cytoplasm
GO:0019005 SCF ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Protein folding pathway
Chaperonin-mediated protein folding pathway
Metabolism of proteins pathway
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Association of TriC/CCT with target proteins during biosynthesis pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
Ubiquitin mediated proteolysis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.165575 Hs.604913
RefSeq NM_001297437 NM_012176 NM_033484 XM_005248287
HUGO
OMIM
CCDS CCDS3938 CCDS3939 CCDS75238
HPRD 09949
IMGT
EMBL
GenPept
RNA Seq Atlas