InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FBXO4

Summary

InnateDB Gene

IDBG-18832.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXO4

Gene Name

F-box protein 4

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000151876

Encoded Proteins

IDBP-18836

F-box protein 4

IDBP-18840

F-box protein 4

IDBP-479233

F-box protein 4

IDBP-473723

F-box protein 4

IDBP-484601

F-box protein 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:41925254-41941743

Strand

Forward strand

Band

p13.1

Transcripts

ENST00000281623	ENSP00000281623
ENST00000296812	ENSP00000296812
ENST00000513496	ENSP00000424750
ENST00000504463	ENSP00000424991
ENST00000509134	ENSP00000421749
ENST00000506496
ENST00000505566

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	21 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0000723	telomere maintenance
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016567	protein ubiquitination
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031398	positive regulation of protein ubiquitination

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005737	cytoplasm
GO:0019005	SCF ubiquitin ligase complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022184

View Gene Order

ENSBTAG00000016981

Not yet available

Pathways

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_16907

Association of TriC/CCT with target proteins during biosynthesis pathway

REACT_16952

Protein folding pathway

REACT_17004

Chaperonin-mediated protein folding pathway

REACT_17015

Metabolism of proteins pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.165575 Hs.604913

RefSeq

NM_001297437 NM_012176 NM_033484 XM_005248287

HUGO

OMIM

CCDS

CCDS3938 CCDS3939 CCDS75238

HPRD

09949

IMGT

EMBL

GenPept

RNA Seq Atlas