Homo sapiens Gene: MYBBP1A
Summary
InnateDB Gene IDBG-18841.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYBBP1A
Gene Name MYB binding protein (P160) 1a
Synonyms P160; PAP2;
Species Homo sapiens
Ensembl Gene ENSG00000132382
Encoded Proteins
MYB binding protein (P160) 1a
MYB binding protein (P160) 1a
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:4538897-4555631
Strand Reverse strand
Band p13.2
Transcripts
ENST00000254718 ENSP00000254718
ENST00000381556 ENSP00000370968
ENST00000572759 ENSP00000460087
ENST00000575662
ENST00000574934
ENST00000571354
ENST00000573723 ENSP00000459692
ENST00000573175
ENST00000574167
ENST00000573116 ENSP00000458919
ENST00000574547
ENST00000571368
ENST00000570986
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 100 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 100 [view]
Protein-Protein 98 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0006261 DNA-dependent DNA replication
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006913 nucleocytoplasmic transport
GO:0022904 respiratory electron transport chain
GO:0042149 cellular response to glucose starvation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0071158 positive regulation of cell cycle arrest
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0042564 NLS-dependent protein nuclear import complex
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.701718
RefSeq NM_001105538 NM_014520 XM_006721419
HUGO
OMIM
CCDS CCDS11046 CCDS42238
HPRD 05349
IMGT
EMBL
GenPept
RNA Seq Atlas