Version 5.4
Mus musculus Gene: Lag3
Summary
InnateDB Gene IDBG-188462.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lag3
Gene Name lymphocyte-activation gene 3
Synonyms CD223; LAG-3; Ly66
Species Mus musculus
Ensembl Gene ENSMUSG00000030124
Encoded Proteins
IDBP-188464
lymphocyte-activation gene 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000089692:
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:124904361-124911705
Strand Reverse strand
Band F2
Transcripts
ENSMUST00000032217 ENSMUSP00000032217
ENSMUST00000139571
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0042289 MHC class II protein binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0045085 negative regulation of interleukin-2 biosynthetic process
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0050868 negative regulation of T cell activation
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000089692
View Gene Order
ENSBTAG00000034295
Not yet available
Cross-References
SwissProt Q61790
TrEMBL
UniProt Splice Variant
Entrez Gene 16768
UniGene Mm.4528
RefSeq NM_008479
OMIM
CCDS CCDS20536
HPRD
IMGT
MGI ID MGI:106588
MGI Symbol Lag3
EMBL BC120591 X98113
GenPept AAI20592 CAA66794
RNA Seq Atlas 16768

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca