Bos taurus Gene: BT.18959
Summary
InnateDB Gene IDBG-640276.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.18959
Gene Name lymphocyte activation gene 3 protein precursor
Synonyms LAG-3
Species Bos taurus
Ensembl Gene ENSBTAG00000034295
Encoded Proteins
Lymphocyte activation gene-3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000089692:
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:104029019-104036158
Strand Reverse strand
Band
Transcripts
ENSBTAT00000048582 ENSBTAP00000045595
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0042289 MHC class II protein binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0045085 negative regulation of interleukin-2 biosynthetic process
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0050868 negative regulation of T cell activation
Cellular Component
GO:0009897 external side of plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.18959
RefSeq NM_001245949
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas