Bos taurus Gene: BT.18959
Summary
InnateDB Gene IDBG-640276.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.18959
Gene Name lymphocyte activation gene 3 protein precursor
Synonyms LAG-3;
Species Bos taurus
Ensembl Gene ENSBTAG00000034295
Encoded Proteins
Lymphocyte activation gene-3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000089692:
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:104029019-104036158
Strand Reverse strand
Band
Transcripts
ENSBTAT00000048582 ENSBTAP00000045595
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0042289 MHC class II protein binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0045085 negative regulation of interleukin-2 biosynthetic process
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0050868 negative regulation of T cell activation
Cellular Component
GO:0009897 external side of plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL E1B7C1
UniProt Splice Variant
Entrez Gene 515155
UniGene Bt.18959
RefSeq NM_001245949
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB608099 DAAA02014457 DAAA02014458
GenPept BAJ61117
RNA Seq Atlas 515155
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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