InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Myh10

Summary

InnateDB Gene

IDBG-188943.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myh10

Gene Name

myosin, heavy polypeptide 10, non-muscle

Synonyms

5730504C04Rik; 9330167F11Rik; Fltn; mKIAA3005; Myhn-2; Myhn2; NMHC II-B; NMHC-B; NMHCII-B; NMMHC II-b; NMMHC-B; NMMHC-IIB; SMemb

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020900

Encoded Proteins

IDBP-188945

myosin, heavy polypeptide 10, non-muscle

IDBP-188947

myosin, heavy polypeptide 10, non-muscle

IDBP-188949

myosin, heavy polypeptide 10, non-muscle

IDBP-264038

myosin, heavy polypeptide 10, non-muscle

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133026:
This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:68691559-68816632

Strand

Forward strand

Band

Transcripts

ENSMUST00000102611	ENSMUSP00000099671
ENSMUST00000018887	ENSMUSP00000018887
ENSMUST00000092984	ENSMUSP00000090661
ENSMUST00000108673	ENSMUSP00000104313
ENSMUST00000141558
ENSMUST00000143032
ENSMUST00000155765
ENSMUST00000145408
ENSMUST00000124006
ENSMUST00000139059

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0030898	actin-dependent ATPase activity
GO:0043531	ADP binding
GO:0051015	actin filament binding

Biological Process

GO:0000281	mitotic cytokinesis
GO:0001701	in utero embryonic development
GO:0001764	neuron migration
GO:0001778	plasma membrane repair
GO:0006200	ATP catabolic process
GO:0006887	exocytosis
GO:0006930	substrate-dependent cell migration, cell extension
GO:0007097	nuclear migration
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0007420	brain development
GO:0007512	adult heart development
GO:0008152	metabolic process
GO:0008283	cell proliferation
GO:0008360	regulation of cell shape
GO:0021592	fourth ventricle development
GO:0021670	lateral ventricle development
GO:0021678	third ventricle development
GO:0021680	cerebellar Purkinje cell layer development
GO:0030036	actin cytoskeleton organization
GO:0030048	actin filament-based movement
GO:0030239	myofibril assembly
GO:0031032	actomyosin structure organization
GO:0031175	neuron projection development
GO:0050885	neuromuscular process controlling balance
GO:0055003	cardiac myofibril assembly
GO:0055015	ventricular cardiac muscle cell development
GO:0060041	retina development in camera-type eye

Cellular Component

GO:0001725	stress fiber
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0016459	myosin complex
GO:0016460	myosin II complex
GO:0030027	lamellipodium
GO:0030424	axon
GO:0030426	growth cone
GO:0030496	midbody
GO:0031594	neuromuscular junction
GO:0032154	cleavage furrow
GO:0042641	actomyosin
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043197	dendritic spine
GO:0097513	myosin II filament