Mus musculus Gene: Myh10
Summary
InnateDB Gene IDBG-188943.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Myh10
Gene Name myosin, heavy polypeptide 10, non-muscle
Synonyms 5730504C04Rik; 9330167F11Rik; Fltn; mKIAA3005; Myhn-2; Myhn2; NMHC II-B; NMHC-B; NMHCII-B; NMMHC II-b; NMMHC-B; NMMHC-IIB; SMemb;
Species Mus musculus
Ensembl Gene ENSMUSG00000020900
Encoded Proteins
myosin, heavy polypeptide 10, non-muscle
myosin, heavy polypeptide 10, non-muscle
myosin, heavy polypeptide 10, non-muscle
myosin, heavy polypeptide 10, non-muscle
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133026:
This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:68691559-68816632
Strand Forward strand
Band B3
Transcripts
ENSMUST00000102611 ENSMUSP00000099671
ENSMUST00000018887 ENSMUSP00000018887
ENSMUST00000092984 ENSMUSP00000090661
ENSMUST00000108673 ENSMUSP00000104313
ENSMUST00000141558
ENSMUST00000143032
ENSMUST00000155765
ENSMUST00000145408
ENSMUST00000124006
ENSMUST00000139059
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 63 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000146 microfilament motor activity
GO:0003774 motor activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0030898 actin-dependent ATPase activity
GO:0043531 ADP binding
GO:0051015 actin filament binding
Biological Process
GO:0000281 mitotic cytokinesis
GO:0001701 in utero embryonic development
GO:0001764 neuron migration
GO:0001778 plasma membrane repair
GO:0006200 ATP catabolic process
GO:0006887 exocytosis
GO:0006930 substrate-dependent cell migration, cell extension
GO:0007097 nuclear migration
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007420 brain development
GO:0007512 adult heart development
GO:0008152 metabolic process
GO:0008283 cell proliferation
GO:0008360 regulation of cell shape
GO:0021592 fourth ventricle development
GO:0021670 lateral ventricle development
GO:0021678 third ventricle development
GO:0021680 cerebellar Purkinje cell layer development
GO:0030036 actin cytoskeleton organization
GO:0030048 actin filament-based movement
GO:0030239 myofibril assembly
GO:0031032 actomyosin structure organization
GO:0031175 neuron projection development
GO:0050885 neuromuscular process controlling balance
GO:0055003 cardiac myofibril assembly
GO:0055015 ventricular cardiac muscle cell development
GO:0060041 retina development in camera-type eye
Cellular Component
GO:0001725 stress fiber
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0016459 myosin complex
GO:0016460 myosin II complex
GO:0030027 lamellipodium
GO:0030424 axon
GO:0030426 growth cone
GO:0030496 midbody
GO:0031594 neuromuscular junction
GO:0032154 cleavage furrow
GO:0042641 actomyosin
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0097513 myosin II filament
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Netrin-1 signaling pathway
EPHA-mediated growth cone collapse pathway
Sema4D induced cell migration and growth-cone collapse pathway
EPH-Ephrin signaling pathway
Axon guidance pathway
Sema4D in semaphorin signaling pathway
Developmental Biology pathway
Semaphorin interactions pathway
KEGG
Tight junction pathway
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Sema4D in semaphorin signaling pathway
Developmental Biology pathway
Semaphorin interactions pathway
Axon guidance pathway
EPHA-mediated growth cone collapse pathway
EPH-Ephrin signaling pathway
Sema4D induced cell migration and growth-cone collapse pathway
EPHA-mediated growth cone collapse pathway
Sema4D in semaphorin signaling pathway
Sema4D induced cell migration and growth-cone collapse pathway
EPH-Ephrin signaling pathway
Axon guidance pathway
Semaphorin interactions pathway
Developmental Biology pathway
KEGG
Tight junction pathway
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.218233 Mm.373160 Mm.408849
RefSeq NM_175260 XM_006534489 XM_006534490 XM_006534491 XM_006534493
OMIM
CCDS CCDS24869
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas