Homo sapiens Gene: MYH10
Summary
InnateDB Gene IDBG-29180.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYH10
Gene Name myosin, heavy chain 10, non-muscle
Synonyms NMMHC-IIB; NMMHCB;
Species Homo sapiens
Ensembl Gene ENSG00000133026
Encoded Proteins
myosin, heavy chain 10, non-muscle
myosin, heavy chain 10, non-muscle
myosin, heavy chain 10, non-muscle
myosin, heavy chain 10, non-muscle
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:8474205-8630761
Strand Reverse strand
Band p13.1
Transcripts
ENST00000379980 ENSP00000369315
ENST00000269243 ENSP00000269243
ENST00000360416 ENSP00000353590
ENST00000411957 ENSP00000408220
ENST00000476737
ENST00000488329
ENST00000465458
ENST00000469865
ENST00000459986
ENST00000472728
ENST00000584124
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 67 [view]
Protein-Protein 67 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000146 microfilament motor activity
GO:0003774 motor activity
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0030898 actin-dependent ATPase activity
GO:0043531 ADP binding
GO:0051015 actin filament binding
Biological Process
GO:0000281 mitotic cytokinesis
GO:0001701 in utero embryonic development
GO:0001764 neuron migration
GO:0001778 plasma membrane repair
GO:0006200 ATP catabolic process
GO:0006887 exocytosis
GO:0006930 substrate-dependent cell migration, cell extension
GO:0007097 nuclear migration
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007420 brain development
GO:0007512 adult heart development
GO:0008152 metabolic process
GO:0008283 cell proliferation
GO:0008360 regulation of cell shape
GO:0021592 fourth ventricle development
GO:0021670 lateral ventricle development
GO:0021678 third ventricle development
GO:0021680 cerebellar Purkinje cell layer development
GO:0030036 actin cytoskeleton organization
GO:0030048 actin filament-based movement
GO:0030239 myofibril assembly
GO:0031032 actomyosin structure organization
GO:0031175 neuron projection development
GO:0050885 neuromuscular process controlling balance
GO:0055003 cardiac myofibril assembly
GO:0055015 ventricular cardiac muscle cell development
GO:0060041 retina development in camera-type eye
Cellular Component
GO:0001725 stress fiber
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0016459 myosin complex
GO:0016460 myosin II complex
GO:0030027 lamellipodium
GO:0030424 axon
GO:0030426 growth cone
GO:0030496 midbody
GO:0031594 neuromuscular junction
GO:0032154 cleavage furrow
GO:0042641 actomyosin
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0097513 myosin II filament
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Sema4D in semaphorin signaling pathway
Developmental Biology pathway
Semaphorin interactions pathway
Axon guidance pathway
EPHA-mediated growth cone collapse pathway
EPH-Ephrin signaling pathway
Sema4D induced cell migration and growth-cone collapse pathway
KEGG
Tight junction pathway
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P35580
TrEMBL E7ERA5 G1UI33 Q9UE82 Q9UMG3
UniProt Splice Variant
Entrez Gene 4628
UniGene Hs.16355
RefSeq NM_001256012 XM_005256651 NM_001256095 NM_005964 XM_005256653
HUGO HGNC:7568
OMIM 160776
CCDS CCDS58515 CCDS11144 CCDS73984
HPRD 01178
IMGT
EMBL AB210026 AB621820 AC011061 AC025518 AC026130 BC000280 BC008968 BC117690 BC117691 BC144668 BC150634 CH471108 M69181 S67247 U15618 U34304 U51039
GenPept AAA84880 AAA87712 AAA99177 AAB28952 AAC50620 AAH00280 AAH08968 AAI17691 AAI17692 AAI44669 AAI50635 BAE06108 BAK64156 EAW90046 EAW90047 EAW90048 EAW90049
RNA Seq Atlas 4628