InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MYH10

Summary

InnateDB Gene

IDBG-635933.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYH10

Gene Name

Myosin-10

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021151

Encoded Proteins

IDBP-687823

Myosin-10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133026:
This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:28680825-28800880

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000028188

ENSBTAP00000028188

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0000166	nucleotide binding
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0030898	actin-dependent ATPase activity
GO:0043531	ADP binding
GO:0051015	actin filament binding

Biological Process

GO:0000281	mitotic cytokinesis
GO:0001701	in utero embryonic development
GO:0001764	neuron migration
GO:0001778	plasma membrane repair
GO:0006200	ATP catabolic process
GO:0006887	exocytosis
GO:0006930	substrate-dependent cell migration, cell extension
GO:0007097	nuclear migration
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0007420	brain development
GO:0007512	adult heart development
GO:0008152	metabolic process
GO:0008283	cell proliferation
GO:0008360	regulation of cell shape
GO:0021592	fourth ventricle development
GO:0021670	lateral ventricle development
GO:0021678	third ventricle development
GO:0021680	cerebellar Purkinje cell layer development
GO:0030036	actin cytoskeleton organization
GO:0030048	actin filament-based movement
GO:0030239	myofibril assembly
GO:0031032	actomyosin structure organization
GO:0031175	neuron projection development
GO:0050885	neuromuscular process controlling balance
GO:0055003	cardiac myofibril assembly
GO:0055015	ventricular cardiac muscle cell development
GO:0060041	retina development in camera-type eye

Cellular Component

GO:0001725	stress fiber
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0016459	myosin complex
GO:0016460	myosin II complex
GO:0030027	lamellipodium
GO:0030424	axon
GO:0030426	growth cone
GO:0030496	midbody
GO:0031594	neuromuscular junction
GO:0032154	cleavage furrow
GO:0042641	actomyosin
GO:0042995	cell projection
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043197	dendritic spine
GO:0097513	myosin II filament