Version 5.4
Homo sapiens Gene: LCAT
Summary
InnateDB Gene IDBG-242762.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LCAT
Gene Name lecithin-cholesterol acyltransferase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000213398
Encoded Proteins
IDBP-37739
lecithin-cholesterol acyltransferase
IDBP-748512
IDBP-750035
IDBP-746252
IDBP-746881
IDBP-745160
IDBP-750506
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:67939750-67944131
Strand Reverse strand
Band q22.1
Transcripts
ENST00000264005 ENSP00000264005
ENST00000575467 ENSP00000460653
ENST00000575277
ENST00000570369 ENSP00000459014
ENST00000570980 ENSP00000464651
ENST00000573538 ENSP00000463220
ENST00000576450 ENSP00000458141
ENST00000570396 ENSP00000459291
ENST00000573846
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity
GO:0005515 protein binding
GO:0008374 O-acyltransferase activity
GO:0034186 apolipoprotein A-I binding
Biological Process
GO:0006629 lipid metabolic process
GO:0006644 phospholipid metabolic process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0008203 cholesterol metabolic process
GO:0030301 cholesterol transport
GO:0034372 very-low-density lipoprotein particle remodeling
GO:0034375 high-density lipoprotein particle remodeling
GO:0034435 cholesterol esterification
GO:0042157 lipoprotein metabolic process
GO:0042158 lipoprotein biosynthetic process
GO:0042632 cholesterol homeostasis
GO:0043691 reverse cholesterol transport
GO:0044281 small molecule metabolic process
GO:0090107 regulation of high-density lipoprotein particle assembly
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0034364 high-density lipoprotein particle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035237
View Gene Order
ENSBTAG00000018043
Not yet available
Pathways
NETPATH
REACTOME
REACT_13621
HDL-mediated lipid transport pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_6823
Lipoprotein metabolism pathway
REACT_111217
Metabolism pathway
REACT_602
Lipid digestion, mobilization, and transport pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.593769
RefSeq NM_000229
HUGO
OMIM
CCDS CCDS10854
HPRD 06098
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca