Mus musculus Gene: Treml4
Summary
InnateDB Gene IDBG-189814.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Treml4
Gene Name triggering receptor expressed on myeloid cells-like 4
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000051682
Encoded Proteins
triggering receptor expressed on myeloid cells-like 4
triggering receptor expressed on myeloid cells-like 4
triggering receptor expressed on myeloid cells-like 4
triggering receptor expressed on myeloid cells-like 4
triggering receptor expressed on myeloid cells-like 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Treml4 is an essential positive regulator of Tlr7 signalling. Treml4(-/-) macrophages are hyporesponsive to Tlr7 agonists and fail to produce type I interferons due to impaired phosphorylation of Stat1 by Mapk14 and decreased recruitment of Myd88 to Tlr7.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188056:
Gene Information
Type Protein coding
Genomic Location Chromosome 17:48264295-48275360
Strand Forward strand
Band C
Transcripts
ENSMUST00000059873 ENSMUSP00000054121
ENSMUST00000154335 ENSMUSP00000118772
ENSMUST00000136272 ENSMUSP00000120550
ENSMUST00000125426 ENSMUSP00000119177
ENSMUST00000153420 ENSMUSP00000115290
ENSMUST00000153131
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Immune System pathway
DAP12 interactions pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL D3YY88
UniProt Splice Variant
Entrez Gene 224840
UniGene Mm.131234
RefSeq NM_001163796 NM_001033922 NM_001163795 NM_172623 XM_006524147
OMIM
CCDS CCDS50140 CCDS28862 CCDS50139 CCDS50141
HPRD
IMGT
MGI ID MGI:1923239
MGI Symbol Treml4
EMBL AC241601
GenPept
RNA Seq Atlas 224840