Version 5.4
Mus musculus Gene: Treml4
Summary
InnateDB Gene IDBG-189814.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Treml4
Gene Name triggering receptor expressed on myeloid cells-like 4
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000051682
Encoded Proteins
IDBP-189816
triggering receptor expressed on myeloid cells-like 4
IDBP-539033
triggering receptor expressed on myeloid cells-like 4
IDBP-531558
triggering receptor expressed on myeloid cells-like 4
IDBP-540091
triggering receptor expressed on myeloid cells-like 4
IDBP-538467
triggering receptor expressed on myeloid cells-like 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25848864
Treml4 is an essential positive regulator of Tlr7 signalling. Treml4(-/-) macrophages are hyporesponsive to Tlr7 agonists and fail to produce type I interferons due to impaired phosphorylation of Stat1 by Mapk14 and decreased recruitment of Myd88 to Tlr7.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188056:
Gene Information
Type Protein coding
Genomic Location Chromosome 17:48264295-48275360
Strand Forward strand
Band C
Transcripts
ENSMUST00000059873 ENSMUSP00000054121
ENSMUST00000154335 ENSMUSP00000118772
ENSMUST00000136272 ENSMUSP00000120550
ENSMUST00000125426 ENSMUSP00000119177
ENSMUST00000153420 ENSMUSP00000115290
ENSMUST00000153131
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000188056
View Gene Order
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_230745
Immune System pathway
REACT_188188
DAP12 interactions pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.131234
RefSeq NM_001033922 NM_001163795 NM_001163796 NM_172623 XM_006524147
OMIM
CCDS CCDS28862 CCDS50139 CCDS50140 CCDS50141
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca