InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Vps4a

Summary

InnateDB Gene

IDBG-190370.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vps4a

Gene Name

vacuolar protein sorting 4a (yeast)

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031913

Encoded Proteins

IDBP-190372

vacuolar protein sorting 4a (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132612:
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:107031222-107045755

Strand

Forward strand

Band

Transcripts

ENSMUST00000034388	ENSMUSP00000034388
ENSMUST00000144527
ENSMUST00000132096

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0009378	four-way junction helicase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0008152	metabolic process
GO:0009838	abscission
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0031565	cytokinesis checkpoint
GO:0032466	negative regulation of cytokinesis
GO:0051301	cell division

Cellular Component

GO:0005737	cytoplasm
GO:0030496	midbody
GO:0031902	late endosome membrane
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000132612

View Gene Order

ENSBTAG00000001659

Not yet available

Pathways

NETPATH

REACTOME

REACT_209837

Membrane Trafficking pathway

REACT_198518

Endosomal Sorting Complex Required For Transport (ESCRT) pathway

KEGG

mmu04144

Endocytosis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_6361

Late Phase of HIV Life Cycle pathway

REACT_27258

Endosomal Sorting Complex Required For Transport (ESCRT) pathway

REACT_6256

HIV Life Cycle pathway

REACT_6185

HIV Infection pathway

REACT_6359

Budding and maturation of HIV virion pathway

REACT_116125

Disease pathway

REACT_11123

Membrane Trafficking pathway

KEGG

hsa04144

Endocytosis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.236004

RefSeq

NM_126165

OMIM

CCDS

CCDS40463

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas