InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: VPS4A

Summary

InnateDB Gene

IDBG-39000.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VPS4A

Gene Name

vacuolar protein sorting 4 homolog A (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000132612

Encoded Proteins

IDBP-39002

vacuolar protein sorting 4 homolog A (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:69311356-69326939

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000254950	ENSP00000254950
ENST00000562754
ENST00000566354
ENST00000564399

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0009378	four-way junction helicase activity
GO:0016887	ATPase activity
GO:0019904	protein domain specific binding
GO:0042623	ATPase activity, coupled

Biological Process

GO:0000910	cytokinesis
GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0009838	abscission
GO:0015031	protein transport
GO:0016032	viral process
GO:0016192	vesicle-mediated transport
GO:0016197	endosomal transport
GO:0019058	viral life cycle
GO:0031565	cytokinesis checkpoint
GO:0032466	negative regulation of cytokinesis
GO:0061024	membrane organization

Cellular Component

GO:0000815	ESCRT III complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030496	midbody
GO:0031902	late endosome membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031913

View Gene Order

ENSBTAG00000001659

Not yet available

Pathways

NETPATH

REACTOME

REACT_6361

Late Phase of HIV Life Cycle pathway

REACT_27258

Endosomal Sorting Complex Required For Transport (ESCRT) pathway

REACT_6256

HIV Life Cycle pathway

REACT_6185

HIV Infection pathway

REACT_6359

Budding and maturation of HIV virion pathway

REACT_116125

Disease pathway

REACT_11123

Membrane Trafficking pathway

KEGG

hsa04144

Endocytosis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.592722 Hs.708924

RefSeq

NM_013245

HUGO

OMIM

CCDS

CCDS45517

HPRD

11676

IMGT

EMBL

GenPept

RNA Seq Atlas