Homo sapiens Gene: VPS4A
Summary
InnateDB Gene IDBG-39000.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VPS4A
Gene Name vacuolar protein sorting 4 homolog A (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000132612
Encoded Proteins
vacuolar protein sorting 4 homolog A (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:69311356-69326939
Strand Forward strand
Band q22.1
Transcripts
ENST00000254950 ENSP00000254950
ENST00000562754
ENST00000566354
ENST00000564399
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0009378 four-way junction helicase activity
GO:0016887 ATPase activity
GO:0019904 protein domain specific binding
GO:0042623 ATPase activity, coupled
Biological Process
GO:0000910 cytokinesis
GO:0006200 ATP catabolic process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0009838 abscission
GO:0015031 protein transport
GO:0016032 viral process
GO:0016192 vesicle-mediated transport
GO:0016197 endosomal transport
GO:0019058 viral life cycle
GO:0031565 cytokinesis checkpoint
GO:0032466 negative regulation of cytokinesis
GO:0061024 membrane organization
Cellular Component
GO:0000815 ESCRT III complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030496 midbody
GO:0031902 late endosome membrane
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Late Phase of HIV Life Cycle pathway
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
HIV Life Cycle pathway
HIV Infection pathway
Budding and maturation of HIV virion pathway
Disease pathway
Membrane Trafficking pathway
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9UN37
TrEMBL A0A024R705 Q9UF30
UniProt Splice Variant
Entrez Gene 27183
UniGene Hs.592722 Hs.708924
RefSeq NM_013245
HUGO HGNC:13488
OMIM 609982
CCDS CCDS45517
HPRD
IMGT
EMBL AF112215 AF132747 AF155740 AF159063 AF255952 AF282903 AK315026 AL133634 BC047932 CH471092
GenPept AAD42971 AAD49227 AAF17203 AAG01470 AAH47932 AAK52408 AAL75948 BAG37514 CAB63758 EAW83263 EAW83264
RNA Seq Atlas 27183