InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tph2

Summary

InnateDB Gene

IDBG-190576.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tph2

Gene Name

tryptophan hydroxylase 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000006764

Encoded Proteins

IDBP-190578

tryptophan hydroxylase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139287:
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:115078641-115185022

Strand

Reverse strand

Band

Transcripts

ENSMUST00000006949	ENSMUSP00000006949
ENSMUST00000155794

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004510	tryptophan 5-monooxygenase activity
GO:0005506	iron ion binding
GO:0016597	amino acid binding
GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

Biological Process

GO:0006587	serotonin biosynthetic process from tryptophan
GO:0007623	circadian rhythm
GO:0008152	metabolic process
GO:0014823	response to activity
GO:0031667	response to nutrient levels
GO:0042427	serotonin biosynthetic process
GO:0043627	response to estrogen
GO:0051384	response to glucocorticoid
GO:0051592	response to calcium ion
GO:0055114	oxidation-reduction process
GO:0071285	cellular response to lithium ion

Cellular Component

GO:0043005

neuron projection

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000139287

View Gene Order

ENSBTAG00000020792

Not yet available

Pathways

NETPATH

REACTOME

REACT_188937

Metabolism pathway

REACT_232845

Metabolism of amino acids and derivatives pathway

REACT_218437

Serotonin and melatonin biosynthesis pathway

REACT_215158

Amine-derived hormones pathway

KEGG

mmu00380

Tryptophan metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_15439

Serotonin and melatonin biosynthesis pathway

REACT_15513

Amine-derived hormones pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00380

Tryptophan metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.31597 Mm.484848

RefSeq

NM_173391

OMIM

CCDS

CCDS36061

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas