Mus musculus Gene: Tph2
Summary
InnateDB Gene IDBG-190576.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tph2
Gene Name tryptophan hydroxylase 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000006764
Encoded Proteins
tryptophan hydroxylase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139287:
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:115078641-115185022
Strand Reverse strand
Band D2
Transcripts
ENSMUST00000006949 ENSMUSP00000006949
ENSMUST00000155794
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004510 tryptophan 5-monooxygenase activity
GO:0005506 iron ion binding
GO:0016597 amino acid binding
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Biological Process
GO:0006587 serotonin biosynthetic process from tryptophan
GO:0007623 circadian rhythm
GO:0008152 metabolic process
GO:0014823 response to activity
GO:0031667 response to nutrient levels
GO:0042427 serotonin biosynthetic process
GO:0043627 response to estrogen
GO:0051384 response to glucocorticoid
GO:0051592 response to calcium ion
GO:0055114 oxidation-reduction process
GO:0071285 cellular response to lithium ion
Cellular Component
GO:0043005 neuron projection
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Metabolism pathway
Metabolism of amino acids and derivatives pathway
Serotonin and melatonin biosynthesis pathway
Amine-derived hormones pathway
KEGG
Tryptophan metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Serotonin and melatonin biosynthesis pathway
Amine-derived hormones pathway
Metabolism of amino acids and derivatives pathway
Metabolism pathway
KEGG
Tryptophan metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.31597 Mm.484848
RefSeq NM_173391
OMIM
CCDS CCDS36061
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas