Version 5.4
Bos taurus Gene: TPH2
Summary
InnateDB Gene IDBG-629839.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TPH2
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020792
Encoded Proteins
IDBP-681357
tryptophan hydroxylase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139287:
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:1524731-1628118
Strand Forward strand
Band
Transcripts
ENSBTAT00000027708 ENSBTAP00000027708
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0004510 tryptophan 5-monooxygenase activity
GO:0005506 iron ion binding
GO:0016597 amino acid binding
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Biological Process
GO:0008152 metabolic process
GO:0009072 aromatic amino acid family metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0043005 neuron projection
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000139287
View Gene Order
ENSMUSG00000006764
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15439
Serotonin and melatonin biosynthesis pathway
REACT_15513
Amine-derived hormones pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_218437
Serotonin and melatonin biosynthesis pathway
REACT_215158
Amine-derived hormones pathway
KEGG
hsa00380
Tryptophan metabolism pathway
mmu00380
Tryptophan metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BGX6
UniProt Splice Variant
Entrez Gene 101909180
UniGene
RefSeq
HUGO HGNC:20692
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02012293 DAAA02012294 DAAA02012295 DAAA02012296 DAAA02012297
GenPept
RNA Seq Atlas 100336620 101909180

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca