Version 5.4
Homo sapiens Gene: TPH2
Summary
InnateDB Gene IDBG-48338.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TPH2
Gene Name tryptophan hydroxylase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000139287
Encoded Proteins
IDBP-48340
tryptophan hydroxylase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:71938846-72186618
Strand Forward strand
Band q21.1
Transcripts
ENST00000333850 ENSP00000329093
ENST00000546576
ENST00000550403
ENST00000547348
ENST00000551074
ENST00000547278
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004510 tryptophan 5-monooxygenase activity
GO:0005506 iron ion binding
GO:0016597 amino acid binding
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Biological Process
GO:0007623 circadian rhythm
GO:0008152 metabolic process
GO:0009072 aromatic amino acid family metabolic process
GO:0014823 response to activity
GO:0031667 response to nutrient levels
GO:0034641 cellular nitrogen compound metabolic process
GO:0042427 serotonin biosynthetic process
GO:0043627 response to estrogen
GO:0044281 small molecule metabolic process
GO:0046219 indolalkylamine biosynthetic process
GO:0051384 response to glucocorticoid
GO:0051592 response to calcium ion
GO:0055114 oxidation-reduction process
GO:0071285 cellular response to lithium ion
Cellular Component
GO:0005829 cytosol
GO:0043005 neuron projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006764
View Gene Order
ENSBTAG00000020792
Not yet available
Pathways
NETPATH
REACTOME
REACT_15439
Serotonin and melatonin biosynthesis pathway
REACT_15513
Amine-derived hormones pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00380
Tryptophan metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.736576
RefSeq NM_173353 XM_005268642
HUGO
OMIM
CCDS CCDS31859
HPRD 09594
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca