Mus musculus Gene: Fkbp4
Summary
InnateDB Gene IDBG-191195.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fkbp4
Gene Name FK506 binding protein 4
Synonyms 59kDa; AL022792; AW208983; FKBP-4; FKBP-52; FKBP52; FKPB52; p59;
Species Mus musculus
Ensembl Gene ENSMUSG00000030357
Encoded Proteins
FK506 binding protein 4
FK506 binding protein 4
FK506 binding protein 4
FK506 binding protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000004478:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:128429735-128438677
Strand Reverse strand
Band F3
Transcripts
ENSMUST00000032508 ENSMUSP00000032508
ENSMUST00000139448 ENSMUSP00000114939
ENSMUST00000150387 ENSMUSP00000119930
ENSMUST00000151796 ENSMUSP00000122087
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 46 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0005528 FK506 binding
GO:0031072 heat shock protein binding
GO:0032767 copper-dependent protein binding
GO:0035259 glucocorticoid receptor binding
GO:0044822 poly(A) RNA binding
GO:0048156 tau protein binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
GO:0006463 steroid hormone receptor complex assembly
GO:0006825 copper ion transport
GO:0007566 embryo implantation
GO:0010977 negative regulation of neuron projection development
GO:0018208 peptidyl-proline modification
GO:0030521 androgen receptor signaling pathway
GO:0030850 prostate gland development
GO:0031111 negative regulation of microtubule polymerization or depolymerization
GO:0031115 negative regulation of microtubule polymerization
GO:0031503 protein complex localization
GO:0046661 male sex differentiation
GO:0048608 reproductive structure development
GO:0061077 chaperone-mediated protein folding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005874 microtubule
GO:0016020 membrane
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043234 protein complex
GO:0044295 axonal growth cone
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Cellular responses to stress pathway
HSF1-dependent transactivation pathway
Cellular response to heat stress pathway
Attenuation phase pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
AndrogenReceptor pathway
REACTOME
Cellular responses to stress pathway
Attenuation phase pathway
HSF1-dependent transactivation pathway
Cellular response to heat stress pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Coregulation of Androgen receptor activity
Glucocorticoid receptor regulatory network
Cross-References
SwissProt
TrEMBL D6RDE2
UniProt Splice Variant
Entrez Gene 14228
UniGene Mm.12758
RefSeq NM_010219
OMIM
CCDS CCDS20573
HPRD
IMGT
MGI ID MGI:95543
MGI Symbol Fkbp4
EMBL AC116573 AC123060
GenPept
RNA Seq Atlas 14228