InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FKBP4

Summary

InnateDB Gene

IDBG-640857.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FKBP4

Gene Name

peptidyl-prolyl cis-trans isomerase FKBP4

Synonyms

FKBP-4; FKBP-52

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007605

Encoded Proteins

IDBP-693160

peptidyl-prolyl cis-trans isomerase FKBP4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000004478:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:107445596-107453517

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000009998

ENSBTAP00000009998

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0005528	FK506 binding
GO:0031072	heat shock protein binding
GO:0035259	glucocorticoid receptor binding
GO:0044822	poly(A) RNA binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0006457	protein folding
GO:0006463	steroid hormone receptor complex assembly
GO:0007566	embryo implantation
GO:0030521	androgen receptor signaling pathway
GO:0030850	prostate gland development
GO:0031503	protein complex localization
GO:0046661	male sex differentiation
GO:0048608	reproductive structure development
GO:0061077	chaperone-mediated protein folding